NUB1 (NYREN18) Antibody (YA8222)
(Synonyms: BS4; NUB1L; NYREN18)NUB1 (NYREN18) Antibody (YA8222) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NUB1 (NYREN18).
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
NUB1 (NYREN18) Antibody (YA8222) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to NUB1 (NYREN18).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 68.9 kDa
Human recombinant protein fragment corresponding to amino acids 1-326 of human NUB1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NUB1 is a Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2
Induction: By TNF, IFNG/IFN-gamma and IFNB1/IFN-beta -
Isoforms & Post-Translational Modification
Q9Y5A7 has two isomers: Q9Y5A7-1: 70538 Da (predicted); Q9Y5A7-2: 69119 Da (predicted).
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Subunit
Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome
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SwissProt ID
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Synonyms
BS4; NUB1L; NYREN18
Documentation
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