NUMB Antibody (YA7750)
(Synonyms: C14orf41; c14_5527; S171)NUMB Antibody (YA7750) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NUMB.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-250 | 1:100 |
Product Details
NUMB Antibody (YA7750) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to NUMB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 69.3 kDa
Full length human recombinant protein of human NUMB produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NUMB regulates clathrin-mediated receptor endocytosis. Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage[1].
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Subcellular Localization
Cell membrane,Endosome membrane
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Isoforms & Post-Translational Modification
P49757 has 9 isomers: P49757-1: 70804 Da (predicted); P49757-2: 65899 Da (predicted); P49757-3: 69431 Da (predicted); P49757-4: 64527 Da (predicted); P49757-5: 55319 Da (predicted); P49757-6: 53947 Da (predicted); P49757-7: 50198 Da (predicted); P49757-8: 48825 Da (predicted); P49757-9: 37396 Da (predicted).
Phosphorylated on Ser-276 and Ser-295 by CaMK1丨Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity) -
Subunit
Interacts with SIAH1 (PubMed:11752454)
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SwissProt ID
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Synonyms
C14orf41; c14_5527; S171
Documentation
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