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OSBP Antibody (YA8211)(PBS only)

(Synonyms: OSBP1)

OSBP Antibody (YA8211) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBP.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, FC

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • OSBP Antibody (YA8211)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
Dilution Ratio 1:1000-4000 1:150-500 1:100-250 1:100

Product Details

Description

OSBP Antibody (YA8211) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OSBP.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 89.2 kDa
Immunogen

Full length human recombinant protein of human OSBP produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    OSBP is a Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability[1][2][3][4].

  • Subcellular Localization

    Cytoplasm, cytosol,Cytoplasm, perinuclear region,Golgi apparatus membrane,Endoplasmic reticulum membrane,Golgi apparatus, trans-Golgi network

  • Expression


    Tissue_Specificity: Widely expressed

  • Isoforms & Post-Translational Modification

    P22059: 807 amino acids, molecular weight 89421 Da.

  • Subunit

    Homodimer or homotrimer

  • SwissProt ID

    P22059

  • Synonyms

    OSBP1

OSBP Antibody (YA8211)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • OSBP Antibody (YA8211)(PBS only) Product Image