PAR6 Antibody (YA7666)

Cat. No.: HY-P87981: Data Sheet User Guide for Antibodies
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PAR6 Antibody (YA7666) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

PAR6 Antibody (YA7666) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.

Host

Rabbit

Clonality

Recombinant

Molecular Weight

Predicted band size: 37 kDa;

Observed band size: 37 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.

SwissProt ID

Q9NPB6

Immunogen

A synthesized peptide derived from human PAR6 alpha

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-2000
FC FC: Flow Cytometry	1:50-100
IP IP: Immunoprecipitation	1:20-50

Sensitivity	Endogenous	Purity	affinity purified by Protein A
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959)

Subcellular Localization：Cytoplasm,Cell membrane,Cell projection, ruffle,Cell junction, tight junction,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Expression：
Tissue_Specificity: Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta

Isoforms & Post-Translational Modification：Q9NPB6 has two isomers: Q9NPB6-1: 37388 Da (predicted); Q9NPB6-2: 37317 Da (predicted).
Phosphorylated by the TGF-beta receptor丨Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation

Subunit：Interacts with MAP2K5 (By similarity)

Documentation

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/a549-cell.html [Content Brief]