PAR6 Antibody (YA7666)
(Synonyms: PAR6A, PARD6A, Partitioning defective 6 homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax interaction protein 40, TIP-40)PAR6 Antibody (YA7666) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC, IP
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Reactivity :
Human
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-100 | 1:20-50 |
Product Details
PAR6 Antibody (YA7666) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAR6.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman Predicted Reactivity: Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 37 kDa
A synthesized peptide derived from human PAR6 alpha
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PAR6 is an Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization[1][2].
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Subcellular Localization
Cytoplasm,Cell membrane,Cell projection, ruffle,Cell junction, tight junction,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Expression
Tissue_Specificity: Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta -
Isoforms & Post-Translational Modification
Q9NPB6 has two isomers: Q9NPB6-1: 37388 Da (predicted); Q9NPB6-2: 37317 Da (predicted).
Phosphorylated by the TGF-beta receptor丨Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation -
Subunit
Interacts with MAP2K5 (By similarity)
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SwissProt ID
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Synonyms
PAR6A, PARD6A, Partitioning defective 6 homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax interaction protein 40, TIP-40
Documentation
[1]. Qiu RG, et al. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr Biol. 2000 Jun 15;10(12):697-707. [Content Brief]
[2]. Kodani A, et al. Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment. Mol Biol Cell. 2010 Oct 1;21(19):3376-85. [Content Brief]
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