country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P87520

PDCD4 Antibody (YA7204)

(Synonyms: H731, PDCD4, Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a)

PDCD4 Antibody (YA7204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDCD4.

For research use only. We do not sell to patients.

Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	IF-Tissue IF-Tissue: Immunofluorescence-Tissue	FC FC: Flow Cytometry
Dilution Ratio	1:500-2000	1:100-500	1:100-500	1:50-200	1:100-500	1:50-100

Description

PDCD4 Antibody (YA7204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PDCD4.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Mouse
Observed Molecular Weight

Observed band size: 52 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 52 kDa

Immunogen

A synthesized peptide derived from human PDCD4: 400-469.

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Solution
Formulation

Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity)
Subcellular Localization

Nucleus,Cytoplasm
Expression

Tissue_Specificity: Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma
Induction: IL2/interleukin-2 stimulation inhibits expression, while IL12/interleukin-12 increases expression
Isoforms & Post-Translational Modification

Q53EL6 has two isomers: Q53EL6-1: 51735 Da (predicted); Q53EL6-2: 50576 Da (predicted).
Polyubiquitinated, leading to its proteasomal degradation丨Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4
Subunit

Interacts (via MI domains) with EIF4A2 (By similarity)
SwissProt ID

Q53EL6
Synonyms

H731, PDCD4, Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a