PICK1 Antibody (YA9783)
(Synonyms: PICK 1, Pick1, PRKCABP)
Based on 1 Customer Validation
PICK1 Antibody (YA9783) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to PICK1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, FC, IP
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
FC
FC: Flow Cytometry
|
IP
IP: Immunoprecipitation
|
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-100 | 1:50 |
Product Details
PICK1 Antibody (YA9783) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to PICK1.
-
Host Rabbit
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 47 kDa
Synthesized peptide derived from human PICK1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PICK1 is a Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function
-
Subcellular Localization
Cytoplasm, perinuclear region; Membrane; Postsynaptic density; Synapse, synaptosome; Cytoplasm, cytoskeleton
-
Expression
Tissue_Specificity: Ubiquitous. -
Isoforms & Post-Translational Modification
PICK1 has 2 isoforms, Q9NRD5-1: amino acid length is 415, molecular weight is 46600 Da (predicted); Q9NRD5-2: amino acid length is 364, molecular weight is 39808 Da (predicted).
Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. -
Subunit
Monomer and homodimer.
-
SwissProt ID
-
Synonyms
PICK 1, Pick1, PRKCABP
Documentation
Powered by Bioz
