PPM1B Antibody (YA7883)
(Synonyms: PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX)PPM1B Antibody (YA7883) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PPM1B.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
PPM1B Antibody (YA7883) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PPM1B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 52.5 kDa
Full length human recombinant protein of human PPM1B produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PPM1B is an Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
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Subcellular Localization
Cytoplasm, cytosol,Membrane
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Expression
Tissue_Specificity: Highly expressed in heart and skeletal muscle -
Isoforms & Post-Translational Modification
O75688 has 5 isomers: O75688-1: 52643 Da (predicted); O75688-2: 42771 Da (predicted); O75688-3: 20753 Da (predicted); O75688-4: 42086 Da (predicted); O75688-5: 36313 Da (predicted).
Isgylation negatively regulates its activity丨N-myristoylation is essential for the recognition of its substrates for dephosphorylation -
Subunit
Monomer (By similarity)
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SwissProt ID
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Synonyms
PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
Documentation
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