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PPP6C Antibody (YA6992)

(Synonyms: FLJ92648 antibody; MGC12249 antibody; PP 6 antibody; PP6 antibody; PP6C antibody; PPP 6 antibody; PPP 6C antibody; PPP6 antibody; PPP6_HUMAN antibody; Ppp6c antibody)
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PPP6C Antibody (YA6992) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPP6C.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF, IHC-P, FC

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • PPP6C Antibody (YA6992) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
FC Info
FC: Flow Cytometry
Dilution Ratio 1:500-1:2000 1:50 1:50-1:100 1:500-1:1000

Product Details

Description

PPP6C Antibody (YA6992) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PPP6C.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 35 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 35 kDa
Immunogen

Synthetic peptide within human PPP6C aa 255-305/305.

Sensitivity

Endogenous

Purification

Protein A affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PPP6C is a Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIGI-mediated signaling activation. Also regulates innate immunity by acting as a negative regulator of the cGAS-STING pathway: mediates dephosphorylation and inactivation of CGAS and STING1. CGAS dephosphorylation at 'Ser-435' impairs its ability to bind GTP, thereby inactivating it[1][2][3][4][5][6][7].

  • Subcellular Localization

    Mitochondrion,Cytoplasm

  • Expression


    Tissue_Specificity: Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen
    Induction: Regulated by IL2/interleukin-2 in peripheral blood T cells

  • Isoforms & Post-Translational Modification

    O00743 has 3 isomers: O00743-1: 35144 Da (predicted); O00743-2: 32532 Da (predicted); O00743-3: 38947 Da (predicted).

  • Subunit

    Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS) (PubMed:18186651)

  • SwissProt ID

    O00743

  • Synonyms

    FLJ92648 antibody; MGC12249 antibody; PP 6 antibody; PP6 antibody; PP6C antibody; PPP 6 antibody; PPP 6C antibody; PPP6 antibody; PPP6_HUMAN antibody; Ppp6c antibody

PPP6C Antibody (YA6992) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • PPP6C Antibody (YA6992) Product Image