SEC24D Antibody (YA9724)
(Synonyms: KIAA0755, Protein transport protein Sec24D, SC24D_HUMAN, SEC24 family member D, SEC24 related gene family, member D, SEC24-related protein D, SEC24D)SEC24D Antibody (YA9724) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to SEC24D.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, ICC/IF, FC, IHC-P
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
FC
FC: Flow Cytometry
|
|---|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:100 | 1:1000-2000 | 1:1000 |
Product Details
SEC24D Antibody (YA9724) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to SEC24D.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 113 kDa;
Synthetic peptide of Human SEC24D (aa 1-50).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
SEC24D is a Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24C may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5[1][2][3].
-
Subcellular Localization
Cytoplasmic vesicle, COPII-coated vesicle membrane; Endoplasmic reticulum membrane; Cytoplasm, cytosol
-
Expression
Tissue_Specificity: Ubiquitously expressed, with higher amounts in placenta, pancreas, heart and liver. -
Isoforms & Post-Translational Modification
SEC24D has 2 isoforms, O94855-1: amino acid length is 1032, molecular weight is 113010 Da (predicted); O94855-2: amino acid length is 1033, molecular weight is 113081 Da (predicted).
-
Subunit
COPII is composed of at least five proteins: the Sec23/24 complex, the Sec13/31 complex and Sar1.
-
SwissProt ID
-
Synonyms
KIAA0755, Protein transport protein Sec24D, SC24D_HUMAN, SEC24 family member D, SEC24 related gene family, member D, SEC24-related protein D, SEC24D
Documentation
References
[1]. Mancias JD, et al. The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope. Mol Cell. 2007 May 11;26(3):403-14. [Content Brief]
[2]. Mancias JD, et al. Structural basis of cargo membrane protein discrimination by the human COPII coat machinery. EMBO J. 2008 Nov 5;27(21):2918-28. [Content Brief]
[3]. Bonnon C, et al. Selective export of human GPI-anchored proteins from the endoplasmic reticulum. J Cell Sci. 2010 May 15;123(Pt 10):1705-15. [Content Brief]
Powered by Bioz
