Syntrophin alpha 1 Antibody (YA1828)
(Synonyms: Alpha 1 syntrophin; LQT12; SNT1; Snta1; Syntrophin 1; TACIP1)
Based on 1 Customer Validation
Syntrophin alpha 1 Antibody (YA1828) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntrophin alpha 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:2000 | 1:100-1:200 | 1:50-1:200 | 1:50-1:100 |
Product Details
Syntrophin alpha 1 Antibody (YA1828) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Syntrophin alpha 1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 54 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 54 kDa
A synthesized peptide derived from human Syntrophin alpha 1 aa1-53/505.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Syntrophin alpha 1 is an Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate
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Subcellular Localization
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side; Cell junction; Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:High expression in skeletal muscle and heart. Low expression in brain, pancreas, liver, kidney and lung. Not detected in placenta -
Isoforms & Post-Translational Modification
Q13424 has 2 isomers: Q13424-1: 53895 Da (predicted); Q13424-2: 45951 Da (predicted).
Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity) -
Subunit
Monomer and homodimer. Interacts with the other members of the syntrophin family SNTB1 and SNTB2; SGCG and SGCA of the dystrophin glycoprotein complex; NOS1; GRB2; the sodium channel proteins SCN4A and SCN5A; F-actin and calmodulin (By similarity). Interacts with dystrophin protein DMD and related proteins DTNA and UTRN and with MAPK12, TGFA and GA. Interacts with MYOC; regulates muscle hypertrophy (By similarity). Interacts with DTNB (By similarity)
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SwissProt ID
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Synonyms
Alpha 1 syntrophin; LQT12; SNT1; Snta1; Syntrophin 1; TACIP1
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Research Field
Signal Transduction
Documentation
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