T Box Protein 3 Antibody (YA7682)
(Synonyms: T-box transcription factor TBX3, T-box protein 3, TBX3)
Based on 1 Customer Validation
T Box Protein 3 Antibody (YA7682) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to T Box Protein 3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP, FC, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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FC
FC: Flow Cytometry
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:20-50 | 1:50-100 | 1:50-200 |
Product Details
T Box Protein 3 Antibody (YA7682) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to T Box Protein 3.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman Predicted Reactivity: Mouse,Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Observed Molecular WeightObserved band size: 79 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 79 kDa
A synthesized peptide derived from human TBX3: 700-743/743.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
T Box Protein 3 transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation. Required for mammary placode induction, and maintenance of the mammary buds during development. Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2. Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling. Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear. Acts as a negative regulator of PML function in cellular senescence[1][2][3].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Widely expressed -
Isoforms & Post-Translational Modification
O15119 has four isomers: O15119-1: 79389 Da (predicted); O15119-2: 77178 Da (predicted); O15119-3: 65604 Da (predicted); O15119-4: Da (predicted).
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Subunit
Interacts with PML (isoform PML-4)
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SwissProt ID
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Synonyms
T-box transcription factor TBX3, T-box protein 3, TBX3
Documentation
References
[1]. He Ml, et al. Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10212-7. [Content Brief]
[2]. Lingbeek ME, et al. The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. J Biol Chem. 2002 Jul 19;277(29):26120-7. [Content Brief]
[3]. Martin N, et al. Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. EMBO J. 2012 Jan 4;31(1):95-109. [Content Brief]
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