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  5. Thioredoxin Reductase 1 Antibody (YA2315)

Thioredoxin Reductase 1 Antibody (YA2315)

Cat. No.: HY-P82570
COA
SDS
User Guide for Antibodies Technical Support

Thioredoxin Reductase 1 Antibody (YA2315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thioredoxin Reductase 1.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Thioredoxin Reductase 1 Antibody (YA2315) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Thioredoxin Reductase 1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 71 kDa;
Observed band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Recombinant protein of human TXNRD1
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:5000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:100-1:200
FC
FC: Flow Cytometry
1:100-1:500
IP
IP: Immunoprecipitation
1:10-1:100
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437); Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions; Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2; Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665)
Subcellular Localization：Cytoplasm; Cytoplasm; Nucleus; Cytoplasm
Expression：
Tissue_specificity:Expressed predominantly in Leydig cells (at protein level) . Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines; Widely expressed with highest levels in kidney, testis, uterus, ovary, prostate, placenta and fetal liver

Induction:Induced by estradiol or testosterone in HeLa cells; Induced by a combination of interferon-beta and retinoic acid (at protein level)
Isoforms & Post-Translational Modification：Q16881 has 7 isomers: Q16881-1: 70906 Da (predicted); Q16881-2: 59787 Da (predicted); Q16881-3: 65567 Da (predicted); Q16881-4: 60419 Da (predicted); Q16881-5: 54754 Da (predicted); Q16881-6: 67266 Da (predicted); Q16881-7: 50873 Da (predicted).
The N-terminus is blocked;ISGylated
Subunit：Homodimer (PubMed:17512005, PubMed:8577704). Interacts with HERC5
Database

Entrez Gene: 7296 Human ; 50493 Mouse ;

SwissProt: Q16881 Human ; Q9JMH6 Mouse ; O89049 Rat

OMIM: 601112 Human

Research Field

Signal Transduction
Synonyms
TR; TR1; TXNR; TRXR1; GRIM-12
Documentation
SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Thioredoxin Reductase 1 Antibody (YA2315) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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