TNF Receptor 2 Antibody (YA3868)(PBS only)

製品番号: HY-P84171A: データシート User Guide for Antibodies
FAQs
Technical Support

TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

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容量		在庫状況
50 μL		お問い合わせ
100 μL		お問い合わせ

* アイテムを追加する前、数量をご選択ください

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

Host

Mouse

分子量

Predicted band size: 48 kDa;

Observed band size: 65 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P20333

Gene ID

7133 [NCBI]

Immunogen

Purified recombinant fragment of human CD120B (AA: extra 23-257) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

純度	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Secreted; Secreted

Isoforms & Post-Translational Modification：P20333 has 2 isomers: P20333-1: 48291 Da (predicted); P20333-2: 28461 Da (predicted).
Phosphorylated; mainly on serine residues and with a very low level on threonine residues;A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing

Subunit：Binds to TRAF2 (PubMed:10206649, PubMed:8069916). Interacts with BMX (PubMed:12370298). Interacts (activated form) with XPNPEP3 (PubMed:25609706)

Synonyms

TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

ドキュメンテーション

User Guide for Antibodies (1077 KB)

TNF Receptor 2 Antibody (YA3868)(PBS only) 関連分類

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TNF Receptor 2 Antibody (YA3868)(PBS only)

Product Detail

Background

説明

TNF Receptor 2 Antibody (YA3868)(PBS only) 関連分類

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