TNF Receptor 2 Antibody (YA3868)(PBS only)

Cat. No.: HY-P84171A: Ficha de datos User Guide for Antibodies
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TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

Host

Mouse

Peso molecular

Predicted band size: 48 kDa;

Observed band size: 65 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse

SwissProt ID

P20333

Gene ID

7133 [NCBI]

Immunogen

Purified recombinant fragment of human CD120B (AA: extra 23-257) expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
FC FC: Flow Cytometry	1:200-1:400
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Pureza	affinity purified.	Conjugation	Non-conjugated
Isotype	IgG2b

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Secreted; Secreted

Isoforms & Post-Translational Modification：P20333 has 2 isomers: P20333-1: 48291 Da (predicted); P20333-2: 28461 Da (predicted).
Phosphorylated; mainly on serine residues and with a very low level on threonine residues;A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing

Subunit：Binds to TRAF2 (PubMed:10206649, PubMed:8069916). Interacts with BMX (PubMed:12370298). Interacts (activated form) with XPNPEP3 (PubMed:25609706)

Synonyms

TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II

Documentación

User Guide for Antibodies (1077 KB)