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TRAIL/CD253 Antibody (YA7083)(PBS only)

(Synonyms: CD253, Trail, Tnfsf10, Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL)

TRAIL/CD253 Antibody (YA7083) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRAIL/CD253.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TRAIL/CD253 Antibody (YA7083)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:400 1:10000

Product Details

Description

TRAIL/CD253 Antibody (YA7083) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRAIL/CD253.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 32.5kDa;
Immunogen

Purified recombinant fragment of human CD253 (AA: extra 39-281) expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TRAIL/CD253 is a Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis[1][2].

  • Subcellular Localization

    Cell membrane,Secreted

  • Expression


    Tissue_Specificity: Widespread; most predominant in spleen, lung and prostate

  • Isoforms & Post-Translational Modification

    P50591 has two isomers: P50591-1: 32509 Da (predicted); P50591-2: 11746 Da (predicted).
    Tyrosine phosphorylated by PKDCC/VLK

  • Subunit

    Homotrimer (PubMed:26457518)

  • SwissProt ID

    P50591

  • Synonyms

    CD253, Trail, Tnfsf10, Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL

TRAIL/CD253 Antibody (YA7083)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TRAIL/CD253 Antibody (YA7083)(PBS only) Product Image