TULP3 Antibody (YA8473)
(Synonyms: TUBL3)TULP3 Antibody (YA8473) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TULP3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
TULP3 Antibody (YA8473) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TULP3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 49.5 kDa
Full length human recombinant protein of human TULP3 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TULP3 is a Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes
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Subcellular Localization
Nucleus,Cell membrane,Cell projection, cilium,Cytoplasm,Secreted
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Expression
Tissue_Specificity: Expressed at high levels in testis, ovaries, thyroid, and spinal cord -
Isoforms & Post-Translational Modification
O75386 has three isomers: O75386-1: 49642 Da (predicted); O75386-2: 56545 Da (predicted); O75386-3: 19273 Da (predicted).
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Subunit
Associates with the IFT complex A (IFT-A) (PubMed:20889716, PubMed:27932497)
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SwissProt ID
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Synonyms
TUBL3
Documentation
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