XPNPEP3 Antibody (YA8311)
(Synonyms: APP3; ICP55; NPHPL1)XPNPEP3 Antibody (YA8311) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to XPNPEP3.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
XPNPEP3 Antibody (YA8311) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to XPNPEP3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 56.9 kDa
Full length human recombinant protein of human XPNPEP3 produced in HEK293 cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
XPNPEP3 catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position |Promotes TNFRSF1B-mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling[1][2].
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Subcellular Localization
Mitochondrion,Cytoplasm,Cytoplasm
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Expression
Tissue_Specificity: Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant -
Isoforms & Post-Translational Modification
Q9NQH7 has 5 isomers: Q9NQH7-1: 57034 Da (predicted); Q9NQH7-2: 48112 Da (predicted); Q9NQH7-3: 31529 Da (predicted); Q9NQH7-4: 54672 Da (predicted); Q9NQH7-5: 32712 Da (predicted).
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Subunit
Homodimer (PubMed:28476889)
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SwissProt ID
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Synonyms
APP3; ICP55; NPHPL1
Documentation
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