ZEB1 Antibody (YA6951)
(Synonyms: AREB 6 antibody; AREB6 antibody; BZP antibody; Delta crystallin enhancer binding factor 1 antibody; DELTA EF1 antibody; FECD6 antibody; MGC133261 antibody; Negative regulator of IL 2 antibody; Negative regulator of IL2 antibody; NIL 2 A antibody)ZEB1 Antibody (YA6951) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZEB1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:1000 | 1:1000 | 1:500-1:1000 |
Product Details
ZEB1 Antibody (YA6951) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ZEB1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 200 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 124 kDa
Recombinant protein within human ZEB1 aa 1-400 / 1,124.
Endogenous
Protein A affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ZEB1 acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas -
Isoforms & Post-Translational Modification
P37275 has 5 isomers: P37275-1: 124074 Da (predicted); P37275-2: 124076 Da (predicted); P37275-3: 116593 Da (predicted); P37275-4: 122003 Da (predicted); P37275-5: 122084 Da (predicted).
Ubiquitinated, leading to degradation in a proteasome-dependent manner -
Subunit
Interacts (via N-terminus) with SMARCA4/BRG1
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SwissProt ID
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Synonyms
AREB 6 antibody; AREB6 antibody; BZP antibody; Delta crystallin enhancer binding factor 1 antibody; DELTA EF1 antibody; FECD6 antibody; MGC133261 antibody; Negative regulator of IL 2 antibody; Negative regulator of IL2 antibody; NIL 2 A antibody
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