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Cat. No.: HY-163153

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Anticancer agent 184

Anticancer agent 184 (Compound 6o) is a novel, effective and low toxic anticancer drug. Anticancer agent 184 induces apoptosis by blocking the S phase.

For research use only. We do not sell to patients.

Formula: C₃₈H₄₂N₂O₁₁
Molecular Weight:702.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Anticancer agent 184 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Anticancer agent 184 (Compound 6o) is a novel, effective and low toxic anticancer drug. Anticancer agent 184 induces apoptosis by blocking the S phase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
JeKo-1	IC₅₀	3.39 μM Compound: 6o	Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay	[PMID: 38352836]
MOLM-13	IC₅₀	3.12 μM Compound: 6o	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay	[PMID: 38352836]
NB-4	IC₅₀	5.25 μM Compound: 6o	Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay Antiproliferative activity against human NB4 cells assessed as inhibition of cell growth incubated for 48 hrs by CCK8 assay	[PMID: 38352836]

Chemical Information

Molecular Weight 702.75
Formula C₃₈H₄₂N₂O₁₁
SMILES

O=C(N1[C@@H]([C@H]2OC(C3=C2C=CC(OC)=C3OC)=O)C4=C(OC)C(OCO5)=C5C(CC6CN(C(OCC7=CC=CC=C7)=O)C6)=C4CC1)OC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li D, et al. Structural Modification of Noscapine via Photoredox/Nickel Dual Catalysis for the Discovery of S-Phase Arresting Agents. ACS Medicinal Chemistry Letters, 2024.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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