2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 210

Anticancer agent 210 (Compound 7a) is a Gefitinib (HY-50895) derivative. Anticancer agent 210 inhibits proliferation, migration and colony formation of cancer cells. Anticancer agent 210 induces apoptosis in cells H1299.

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Anticancer agent 210 Chemical Structure

Anticancer agent 210 Chemical Structure

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Anticancer agent 210 Related Antibodies

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Description

Anticancer agent 210 (Compound 7a) is a Gefitinib (HY-50895) derivative. Anticancer agent 210 inhibits proliferation, migration and colony formation of cancer cells. Anticancer agent 210 induces apoptosis in cells H1299[1].

In Vitro

Anticancer agent 210 (0-32 μM, 48 h) inhibits proliferation of lung cancer cells NCI-H1299, A549, NCI-H1437, with IC50s of 3.94, 3.16 and 1.84 μM, respectively[1].
Anticancer agent 210 (2-16 μM, 48 h) exhibits slightly cytotoxicity in normal hepatocytes L02, with IC50 of 18.87 μM, and a survival rate >60%[1].
Anticancer agent 210 (4-16 μM, 48 h) induces apoptosis of non-small cell lung cancer cells through Bcl-2/caspase3/PARP pathway, inhibits NSCLC cell migration through suppression of MMP9 protein expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 210 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: NCI-H1299, A549, NCI-H1437
Concentration: 0-32 μM
Incubation Time: 48 h
Result: Inhibited cell proliferation.

Western Blot Analysis[1]

Cell Line: NCI-H1299
Concentration: 4-16 μM
Incubation Time: 48 h
Result: Inhibited expressions of Bcl-2, caspase9 and MMP9, upregulated levels of cleaved caspase 3 and PARP.
In Vivo

Anticancer agent 210 (400 mg/kg, p.o., single dose) exhibits no significant toxicity in Kunming mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

648.53

Formula

C31H31BrFN7O3
Unlabeled Cas

SMILES

COC(C=C(N=CN=C1NC2=CC(C3=CN(CC4=C(Br)C=CC(F)=C4)N=N3)=CC=C2)C1=C5)=C5OCCCN6CCOCC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 210 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 210Anticancer agent210Anticancer agent-210ApoptosisNCI-H1299A549NCI-H1437Kunming mouseL02NSCLCInhibitorinhibitorinhibit

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