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United States

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製品番号: HY-162481

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Anticancer agent 210

Anticancer agent 210 (Compound 7a) is a Gefitinib (HY-50895) derivative. Anticancer agent 210 inhibits proliferation, migration and colony formation of cancer cells. Anticancer agent 210 induces apoptosis in cells H1299.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3052009-28-3
分子式: C₃₁H₃₁BrFN₇O₃
分子量:648.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Anticancer agent 210 構造式

CAS 番号: 3052009-28-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Anticancer agent 210 (0-32 μM, 48 h) inhibits proliferation of lung cancer cells NCI-H1299, A549, NCI-H1437, with IC₅₀s of 3.94, 3.16 and 1.84 μM, respectively^[1].
Anticancer agent 210 (2-16 μM, 48 h) exhibits slightly cytotoxicity in normal hepatocytes L02, with IC₅₀ of 18.87 μM, and a survival rate >60%^[1].
Anticancer agent 210 (4-16 μM, 48 h) induces apoptosis of non-small cell lung cancer cells through Bcl-2/caspase3/PARP pathway, inhibits NSCLC cell migration through suppression of MMP9 protein expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

NCI-H1299, A549, NCI-H1437
Concentration:

0-32 μM
Incubation Time:

48 h
Result:

Inhibited cell proliferation.

Western Blot Analysis^[1]

Cell Line:

NCI-H1299
Concentration:

4-16 μM
Incubation Time:

48 h
Result:

Inhibited expressions of Bcl-2, caspase9 and MMP9, upregulated levels of cleaved caspase 3 and PARP.

体内実験

Anticancer agent 210 (400 mg/kg, p.o., single dose) exhibits no significant toxicity in Kunming mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3052009-28-3
分子量 648.53
分子式 C₃₁H₃₁BrFN₇O₃
SMILES

COC(C=C(N=CN=C1NC2=CC(C3=CN(CC4=C(Br)C=CC(F)=C4)N=N3)=CC=C2)C1=C5)=C5OCCCN6CCOCC6
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gao E, et al., Discovery of gefitinib-1,2,3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation. Sci Rep. 2024 Apr 22;14(1):9223. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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