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  5. Anticancer agent 25

Anticancer agent 25 is an anticancer agent. Anticancer agent 25 can arrest the cell cycle at the G1 phase, and significantly inhibit tumor cell colony forming and migration even at low concentrations. Anticancer agent 25 can significantly induce cytoplasmic vacuolation. Anticancer agent 25 can be used for the study of prostate cancer, breast cancer, and colon cancer.

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Anticancer agent 25

Anticancer agent 25 Chemical Structure

CAS No. : 2401013-08-7

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Anticancer agent 25 Related Antibodies

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Description

Anticancer agent 25 is an anticancer agent. Anticancer agent 25 can arrest the cell cycle at the G1 phase, and significantly inhibit tumor cell colony forming and migration even at low concentrations. Anticancer agent 25 can significantly induce cytoplasmic vacuolation. Anticancer agent 25 can be used for the study of prostate cancer, breast cancer, and colon cancer[1].

IC50 & Target

Cell Cycle/DNA Damage

0.19 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
DU-145 IC50
0.74 μM
Compound: 18e
Antiproliferative activity against human DU145 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human DU145 cells assessed as cell growth inhibition by SRB assay
[PMID: 31812467]
HCT-116 IC50
0.55 μM
Compound: 18e
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition by SRB assay
[PMID: 31812467]
HT-29 IC50
0.56 μM
Compound: 18e
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition by SRB assay
[PMID: 31812467]
MDA-MB-231 IC50
1.31 μM
Compound: 18e
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition by SRB assay
[PMID: 31812467]
PC-3 IC50
0.19 μM
Compound: 18e
Antiproliferative activity against human PC3 cells assessed as cell growth inhibition by SRB assay
Antiproliferative activity against human PC3 cells assessed as cell growth inhibition by SRB assay
[PMID: 31812467]
In Vitro

Anticancer agent 25 (Compound 18e) shows antiproliferative activity against prostate cancer cell lines, PC3 (IC50 = 0.19 μM) and DU145 (IC50 = 0.74 μM); breast cancer cell line MDA-MB-231 (IC50 = 1.31 μM); and human colon cancer cell lines, HT29 (IC50 = 0.56 μM) and HCT116 (IC50 = 0.55 μM); and exhibits low toxicity against normal human aortic fibroblasts (HAF) (IC50 = 3.95 μM)[1].
Anticancer agent 25 (0.5-2 μM, 24 h) induces G1 phase arrest in PC3 cells in a dose-dependent manner[1].
Anticancer agent 25 (0.1-2 μM, 24 h) can significantly inhibit the long-term proliferation ability of PC3 tumor cells even at extremely low concentrations[1].
Anticancer agent 25 (0.1-2 μM, 24 h) significantly and in a dose-dependent manner inhibits the migration ability of PC3 cells[1].
Anticancer agent 25 (0.5-1 μM, 24 h) can induce significant cytoplasmic vacuolation in PC3 cells even at low concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 25 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: PC3 cells
Concentration: 0.5 μM, 1 μM, 2 μM
Incubation Time: 24 h
Result: Caused ~ 50% inhibition on the colony forming at 0.1 μM and ~ 90% inhibition at 0.5 μM.
Molecular Weight

645.67

Formula

C37H45BrN2O3
CAS No.
SMILES

CC(C)C(C=C1)=CC=C1CC2=C3C=CC(OC)=C(NCCCCCCCC)C3=C[N+]4=C2C5=CC6=C(C=C5CC4)OCO6.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 25 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 252401013-08-7Anticancer agent25Anticancer agent-25OthersBerberine derivativesLipophilic groupAnticancer activityColony formingCell migrationInhibitorinhibitorinhibit

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