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  3. Anticancer agent 45

Anticancer agent 45 

Cat. No.: HY-146290
Handling Instructions

Anticancer agent 46 (compound 2b) is a potent and selective anticancer agent. Anticancer agent 46 shows cytotoxicity activity in cancer cells. Anticancer agent 46 induces apoptosis. Anticancer agent 46 shows low toxicity towards activated lymphocytes of human blood.

For research use only. We do not sell to patients.

Anticancer agent 45 Chemical Structure

Anticancer agent 45 Chemical Structure

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Description

Anticancer agent 46 (compound 2b) is a potent and selective anticancer agent. Anticancer agent 46 shows cytotoxicity activity in cancer cells. Anticancer agent 46 induces apoptosis. Anticancer agent 46 shows low toxicity towards activated lymphocytes of human blood[1].

In Vitro

Anticancer agent 46 (compound 2b) (0-100 µM; 72 h) shows antitumor activity with GI50S of 1.30, 7.25, 4.00, 6.20, 8.00, 6.13, 4.52, 5.65, 1.10, >100, 73.62 µM for Jurkat, A549, MCF-7, MDA-MB-231, KB3-1, HeLa, HCT-116, HCT-116 p53-/-, U251, SK-OV-3, HaCaT cells, respectively[1].
Anticancer agent 46 (1.5 µM; 24 h) induces apoptosis by increases the expression of caspase 3, Bax and decreases the amount of anti-apoptotic Bcl-2 protein[1].
Anticancer agent 46 (compound 2b) (0-2 µM; 24, 48 h) shows low toxicity towards normal human keratinocytes of HaCaT line and mitogen-activated lymphocytes of peripheral blood of healthy human donor[1].
Anticancer agent 46 dose not induce significant DNA damage and changes in morphology of mitogen-activated lymphocytes of peripheral blood of healthy donor[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Jurkat cells
Concentration: 1.5 µM
Incubation Time: 24 h
Result: Increased in the amount of pro-apoptotic proteins: caspase 3, Bax, and decreased the amount of anti-apoptotic Bcl-2 protein.
Molecular Weight

515.95

Formula

C22H14ClN3O6S2

SMILES

O=C(C(N(C/1=O)C(SC1=C/C(Cl)=C/C2=CC=C([N+]([O-])=O)C=C2)=S)C3)N(C4=CC=C(O)C=C4)C3=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Anticancer agent 45
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HY-146290
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