Antiproliferative agent-14
Based on 1 Customer Validation
Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.
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- Pureté : 98.76%
- CAS No.: 1885900-35-5
- Formule: C21H18FN3O2
- Masse moléculaire:363.38
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.013 μM
Compound: 3b
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Cytotoxicity against human HeLa cells after 3 days by SRB assay
Cytotoxicity against human HeLa cells after 3 days by SRB assay
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[PMID: 26927488] |
In Vitro
Antiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC50=13 nM)[1].
Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1885900-35-5
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Appearance Solid
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Masse moléculaire 363.38
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Formule C21H18FN3O2
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Color Light yellow to yellow
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SMILES
COC1=CC=C(C=C1)CNC2=C(N=C3C=CC(F)=CN32)C4=C(C=CC=C4)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (275.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7519 mL | 13.7597 mL | 27.5194 mL | 68.7985 mL |
| 5 mM | 0.5504 mL | 2.7519 mL | 5.5039 mL | 13.7597 mL | |
| 10 mM | 0.2752 mL | 1.3760 mL | 2.7519 mL | 6.8799 mL | |
| 15 mM | 0.1835 mL | 0.9173 mL | 1.8346 mL | 4.5866 mL | |
| 20 mM | 0.1376 mL | 0.6880 mL | 1.3760 mL | 3.4399 mL | |
| 25 mM | 0.1101 mL | 0.5504 mL | 1.1008 mL | 2.7519 mL | |
| 30 mM | 0.0917 mL | 0.4587 mL | 0.9173 mL | 2.2933 mL | |
| 40 mM | 0.0688 mL | 0.3440 mL | 0.6880 mL | 1.7200 mL | |
| 50 mM | 0.0550 mL | 0.2752 mL | 0.5504 mL | 1.3760 mL | |
| 60 mM | 0.0459 mL | 0.2293 mL | 0.4587 mL | 1.1466 mL | |
| 80 mM | 0.0344 mL | 0.1720 mL | 0.3440 mL | 0.8600 mL | |
| 100 mM | 0.0275 mL | 0.1376 mL | 0.2752 mL | 0.6880 mL |
Antiproliferative agent-14 Related Classifications
HY-148265 Related Classifications
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