2. Immunology/Inflammation
  3. Complement System
  4. ANX-M1 (Mouse IgG1)

ANX-M1 Mouse IgG1 is a brain-penetrant C1q inhibitor. ANX-M1 Mouse IgG1 blocks classical complement pathway activation, reduces C1q concentrations in brain and plasma, and inhibits microglia-mediated synapse engulfment. ANX-M1 Mouse IgG1 can be used for the research of Huntington's disease, Alzheimer's disease, retinopathy and neuropathic pain.

For research use only. We do not sell to patients.

ANX-M1 (Mouse IgG1)

ANX-M1 (Mouse IgG1) Chemical Structure

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ANX-M1 (Mouse IgG1) Related Antibodies

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Description

ANX-M1 Mouse IgG1 is a brain-penetrant C1q inhibitor. ANX-M1 Mouse IgG1 blocks classical complement pathway activation, reduces C1q concentrations in brain and plasma, and inhibits microglia-mediated synapse engulfment. ANX-M1 Mouse IgG1 can be used for the research of Huntington's disease, Alzheimer's disease, retinopathy and neuropathic pain[1][2][3][4].

Isotype

Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human/Mouse
In Vitro

ANX-M1 Mouse IgG1 prevents amyloid-beta oligomer-induced inhibition of long-term potentiation in wild-type mouse hippocampal slices[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ANX-M1 (Mouse IgG1) Related Antibodies
In Vivo

ANX-M1 Mouse IgG1 (intracerebroventricula) prevents amyloid-beta oligomer-induced synapse loss in wild-type mice, maintaining synapse density near baseline levels[2].
ANX-M1 Mouse IgG1 (7.5 μg/μL; intravitreal; single dose) reduces photoreceptor cell death, preserves retinal structure, and improves retinal function in a mouse model of photo-oxidative retinal degeneration[4].
ANX-M1 Mouse IgG1 (7.5 μg/μL; intravitreal; single dose) does not protect against photo-oxidative retinal degeneration in mice[4].
ANX-M1 Mouse IgG1 (100 mg/kg; intraperitoneal; 3 doses) inhibits serum complement activity but does not protect against photo-oxidative retinal degeneration in mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J (adult, postnatal day 60-90, equal numbers of male and female, photo-oxidative damage-induced retinal degeneration)[4]
Dosage: 7.5 μg/μL (1 μl volume per eye)
Administration: intravitreal; single dose
Result: Significantly reduced the number of TUNEL+ photoreceptor cells in the outer nuclear layer at day 14.
Significantly increased outer nuclear layer thickness (measured as rows of photoreceptor nuclei).
Significantly improved rod a-wave and b-wave electroretinography amplitudes, with the most pronounced differences at the highest flash intensity (1.9 log cd.s/m2).
Significantly increased cone electroretinography amplitudes.
Showed no significant difference in the number of IBA1+ microglia/macrophages in the outer retina and outer nuclear layer compared to control.\nShowed no significant differences in the number of TUNEL+ photoreceptor cells, outer nuclear layer thickness, number of IBA1+ microglia/macrophages in the outer retina, rod a-wave and b-wave electroretinography amplitudes, or cone electroretinography amplitudes at day 14 compared to control.
Animal Model: C57BL/6 J (adult, postnatal day 60-90, equal numbers of male and female, photo-oxidative damage-induced retinal degeneration)[4]
Dosage: 100 mg/kg
Administration: intraperitoneal; 3 doses (day 0, day 4, day 8)
Result: Reduced serum complement activity by >50% compared to IgG isotype control at day 12.
Showed no significant differences in the number of TUNEL+ photoreceptor cells, outer nuclear layer thickness, number of IBA1+ microglia/macrophages in the outer retina, rod a-wave and b-wave electroretinography amplitudes, or cone electroretinography amplitudes at day 12 compared to control.
Gene ID

712  [NCBI]

Accession
Target

C1q
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[ANX-M1 (Mouse IgG1)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ANX-M1 (Mouse IgG1) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANX-M1 (Mouse IgG1)Complement SystemHuntington's diseaseC1qcerebrospinal fluidamyloid-beta oligomerclassical complement pathwaymicrogliahippocampal long-term potentiationR6/2 miceAlzheimer's diseaseneurofilament light chainInhibitorinhibitorinhibit

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