AR antagonist 1 hydrochloride
Based on 1 Customer Validation
AR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020).
For research use only. We do not sell to patients.
- Purity: 99.53%
- CAS No.: 1818885-55-0
- Formula: C15H20Cl2N2O
- Molecular Weight:315.24
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Anti-Cancer Compound Library
HY-L025
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Ubiquitination Compound Library
HY-L050
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Transcription Factor-Targeted Library
HY-L090
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Anti-Prostate Cancer Compound Library
HY-L124
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Nuclear Receptor Compound Library
HY-L126
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E3 Ligase Ligand Library
HY-L128
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Target Protein Ligand Library
HY-L129
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Highly Selective Inhibitors Library
HY-L158
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
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VHL |
AR antagonist 1 (compound 29) hydrochloride is the ligand for target ligase of ARD-266. ARD-266 is a highly potent and VHL E3 ligase-based androgen receptor (AR) PROTAC degrader[1]. AR antagonist 1 exhibits micromolar binding affinity to its E3 ligase complex, it can be successfully employed for the design of highly potent and efficient PROTAC degraders[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1818885-55-0
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Appearance Solid
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Molecular Weight 315.24
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Formula C15H20Cl2N2O
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Color White to off-white
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SMILES
[H]Cl.N#CC1=CC=C(O[C@H]2C(C)(C)[C@H](N)C2(C)C)C=C1Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 58.33 mg/mL (185.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.1721 mL | 15.8607 mL | 31.7215 mL | 79.3037 mL |
| 5 mM | 0.6344 mL | 3.1721 mL | 6.3443 mL | 15.8607 mL | |
| 10 mM | 0.3172 mL | 1.5861 mL | 3.1721 mL | 7.9304 mL | |
| 15 mM | 0.2115 mL | 1.0574 mL | 2.1148 mL | 5.2869 mL | |
| 20 mM | 0.1586 mL | 0.7930 mL | 1.5861 mL | 3.9652 mL | |
| 25 mM | 0.1269 mL | 0.6344 mL | 1.2689 mL | 3.1721 mL | |
| 30 mM | 0.1057 mL | 0.5287 mL | 1.0574 mL | 2.6435 mL | |
| 40 mM | 0.0793 mL | 0.3965 mL | 0.7930 mL | 1.9826 mL | |
| 50 mM | 0.0634 mL | 0.3172 mL | 0.6344 mL | 1.5861 mL | |
| 60 mM | 0.0529 mL | 0.2643 mL | 0.5287 mL | 1.3217 mL | |
| 80 mM | 0.0397 mL | 0.1983 mL | 0.3965 mL | 0.9913 mL | |
| 100 mM | 0.0317 mL | 0.1586 mL | 0.3172 mL | 0.7930 mL |
AR antagonist 1 hydrochloride Related Classifications
HY-130845A Related Classifications
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