2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. ARC 239

ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM.

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ARC 239

ARC 239 構造式

CAS 番号 : 67339-62-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 104 在庫あり
Solution
10 mM * 1 mL in DMSO USD 104 在庫あり
Solid
5 mg $95 在庫あり
10 mg $165 在庫あり
25 mg $345 在庫あり
50 mg $550 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

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Based on 2 publication(s) in Google Scholar

Other Forms of ARC 239:

ARC 239 関連抗体

Top Publications Citing Use of Products

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
α adrenergic receptor β adrenergic receptor

5-HT Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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製品説明

ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].

IC50 & Target[1][2]

human α2C-adrenoceptor

6.95 (pKi)

5-HT1A Receptor

 

Alpha-2C adrenergic receptor

7.06 (pKi)

5-HT1A Receptor

63.1 nM (Ki)

分子量

407.51

分子式

C24H29N3O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (122.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4539 mL 12.2696 mL 24.5393 mL
5 mM 0.4908 mL 2.4539 mL 4.9079 mL
10 mM 0.2454 mL 1.2270 mL 2.4539 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4539 mL 12.2696 mL 24.5393 mL 61.3482 mL
5 mM 0.4908 mL 2.4539 mL 4.9079 mL 12.2696 mL
10 mM 0.2454 mL 1.2270 mL 2.4539 mL 6.1348 mL
15 mM 0.1636 mL 0.8180 mL 1.6360 mL 4.0899 mL
20 mM 0.1227 mL 0.6135 mL 1.2270 mL 3.0674 mL
25 mM 0.0982 mL 0.4908 mL 0.9816 mL 2.4539 mL
30 mM 0.0818 mL 0.4090 mL 0.8180 mL 2.0449 mL
40 mM 0.0613 mL 0.3067 mL 0.6135 mL 1.5337 mL
50 mM 0.0491 mL 0.2454 mL 0.4908 mL 1.2270 mL
60 mM 0.0409 mL 0.2045 mL 0.4090 mL 1.0225 mL
80 mM 0.0307 mL 0.1534 mL 0.3067 mL 0.7669 mL
100 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.6135 mL
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ARC 239 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARC 23967339-62-2ARC239ARC-239Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptorα2B/C-adrenergic receptor antagonist5-HT1A receptorInhibitorinhibitorinhibit

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製品名:
ARC 239
製品番号:
HY-12709
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