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Art. -Nr.: HY-19887

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Tilapertin

Name: Tilapertin
Brand: MedChemExpress
SKU: HY-19887
Availability: PreOrder

(Synonyms: AMG747)

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1000690-85-6
Formel: C₂₀H₂₁F₃N₂O₂
Molecular Weight:378.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Tilapertin Chemical Structure

CAS. Nr.: 1000690-85-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

IC₅₀ & Target

GlyT1

Alle GlyT Isoform-spezifische Produkte anzeigen :

GlyT1
GlyT2

In Vivo

Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 1000690-85-6
Molecular Weight 378.39
Formel C₂₀H₂₁F₃N₂O₂
SMILES

O=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1
Synonyms

AMG747
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
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Reinheit:
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Tilapertin

Bitopertin

Bitopertin (R enantiomer)

Bitopertin (Standard)

GlyT1 Inhibitor 1

LY2365109 hydrochloride

Iclepertin

Org 25543 hydrochloride

(Rac)-ALX 5407

LY2365109 hydrochloride (Standard)

PF-03463275

ASP2535

SSR504734

Alle GlyT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Bioz

Tilapertin

Bitopertin

Bitopertin (R enantiomer)

Bitopertin (Standard)

GlyT1 Inhibitor 1

LY2365109 hydrochloride

Iclepertin

Org 25543 hydrochloride

(Rac)-ALX 5407

LY2365109 hydrochloride (Standard)

PF-03463275

ASP2535

SSR504734

Alle GlyT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Tilapertin Related Classifications

HY-19887 Related Classifications

Bioz