155206-00-1
Chemical Structure
Bimatoprost
Synonym(s): AGN 192024
- CAS. Nr.: 155206-00-1
- Formula:C25H37NO4
- Molecular Weight:415.57
IUPAC Name: (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide
InChIKey: AQOKCDNYWBIDND-FTOWTWDKSA-N
SMILES: O=C(NCC)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O
Biological Activity: Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus[1][2][3][4][5][6].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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Bimatoprost | 99.98% | Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus. | ||||||||||||||||||||
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Bimatoprost (Standard) | ≥98% | Bimatoprost (Standard) is the analytical standard of Bimatoprost. This product is intended for research and analytical applications. Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus. | ||||||||||||||||||||
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Bimatoprost-d5 | 98.24% | Bimatoprost-d5 is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect. | ||||||||||||||||||||
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Bimatoprost-d4 | Bimatoprost-d4 is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. | |||||||||||||||||||||
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References
- [1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7. [Content Brief]
- [2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7. [Content Brief]
- [3]. Stamer W D, et al. Proposed mechanism of long-term intraocular pressure lowering with the bimatoprost implant[J]. Investigative Ophthalmology & Visual Science, 2023, 64(3): 15-15. [Content Brief]
- [4]. Patil A J, et al. Bimatoprost–a review[J]. Expert opinion on pharmacotherapy, 2009, 10(16): 2759-2768. [Content Brief]
- [5]. Woodward, et al. "Bimatoprost: a novel antiglaucoma agent." Cardiovascular drug reviews 22.2 (2004): 103-120. [Content Brief]
- [6]. Crowston, et al. "Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice." Investigative ophthalmology & visual science 46.12 (2005): 4571-4577. [Content Brief]
