CMLD012073
CMLD012073 is an amidino-rocaglates and is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. CMLD012073 inhibits the growth of NIH/3T3 cells with an IC50 of 10 nM. CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
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- CAS. Nr.: 2368900-32-5
- Formel: C30H30N2O7
- Molecular Weight:530.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
eIF4A[1]
In in vitro translation assays, CMLD012073 is potent at inhibiting cap-dependent translation (FF). In ribosome recruitment experiments, CMLD012073 inhibits assembly of the 80S ribosome on the mRNA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2368900-32-5
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Molecular Weight 530.57
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Formel C30H30N2O7
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SMILES
CC1=N[C@@]2(O)[C@H](C(OC)=O)[C@@H](C3=CC=CC=C3)[C@]4(C5=CC=C(OC)C=C5)OC6=C(C(OC)=CC(OC)=C6)[C@@]42N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CMLD012073 Related Classifications
HY-129769 Related Classifications
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