CP 154526
CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 has anxiolytic activities.
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- CAS. Nr.: 157286-86-7
- Formel: C23H32N4
- Molecular Weight:364.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
0.011 μM
Compound: 8, CP-154,526
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Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cells
Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cells
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[PMID: 21414781] |
CP 154526 displaces [125I][Tyr0]CRF from rat hippocampal CRF receptors (IC50 = 0.5 nM) and from pituitary CRF receptors (IC50 = 0.04 nM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats[2]
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Dosage:1 mg/kg, 3 mg/kg, 10 mg/kg
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Administration:i.p.; once
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Result:Exhibited signs of anxiolytic-like activity.
Chemical Information
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CAS. Nr. 157286-86-7
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Molecular Weight 364.53
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Formel C23H32N4
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SMILES
CC1=C(N2C=C(C)C3=C(N(CCCC)CC)N=C(C)N=C32)C(C)=CC(C)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. J Lundkvist, et al. A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur J Pharmacol. 1996 Aug 8;309(2):195-200. [Content Brief]
[2]. D W Schulz, et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10477-82. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CP 154526 Related Classifications
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