Delapril
Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 83435-66-9
- Formel: C26H32N2O5
- Molecular Weight:452.54
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Delapril (1-10 mg/kg, p.o., daily for 5 weeks) shows antihypertensive effect spontaneously in hypertensive rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Cholesterol-fed rabbits[2]
-
Dosage:5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20
-
Administration:Fed in a fixed volume (10 ml) of drinking water
-
Result:Decreased aortic area covered by lesions.
Restored endothelium-dependent relaxation
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS. Nr. 83435-66-9
-
Molecular Weight 452.54
-
Formel C26H32N2O5
-
SMILES
CCOC([C@H](CCC1=CC=CC=C1)N[C@@H](C)C(N(C2CC3=C(C=CC=C3)C2)CC(O)=O)=O)=O
-
Synonyms
CV-3317
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43(3):242-9. [Content Brief]
[2]. Hernandez A,et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137(1):71-6. [Content Brief]
[3]. Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42(1):1-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Delapril Related Classifications
HY-121232 Related Classifications
Powered by Bioz