country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-133900

Copy Link Print Information

Deoxyharringtonine

Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 36804-95-2
Formel: C₂₈H₃₇NO₈
Molecular Weight:515.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Deoxyharringtonine Chemical Structure

CAS. Nr.: 36804-95-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	0.02 μM Compound: Deoxyharringtonine	Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay	10.1039/C0MD00241K
P388	IC₅₀	0.0075 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	10.1021/np9604543
P388	IC₅₀	0.0075 μg/mL Compound: 5	Antileukemic activity against P-388 leukemia cells. Antileukemic activity against P-388 leukemia cells.	10.1016/0960-894X(96)00302-2
P388	IC₅₀	0.0075 μg/mL Compound: deoxyharringtonine	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	10.1021/np9605044

In Vitro

Deoxyharringtonine acts on P388 leukemia cells with the IC₅₀ value of 7.5 ng/mL. In addition, it has strong cytotoxic activity against hematopoietic cell lines such as HL-60, HL-60/RV+, JURKAT, ALL3, NCEB1, JEKO, MOLT-3, etc^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 36804-95-2
Molecular Weight 515.60
Formel C₂₈H₃₇NO₈
SMILES

COC1=C[C@]23N(CCC3)CCC4=CC5=C(OCO5)C=C4[C@]2([H])[C@@H]1OC([C@@](CC(OC)=O)(O)CCC(C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Joseph D Eckelbarger, et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry. 2008;14(14):4293-306. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen