FAAH-IN-5
FAAH-IN-5 is a dual FAAH/MAGL inhibitor with IC50 values of 0.0105 μM and 0.284 μM, respectively. FAAH-IN-5 shows reduced PAMPA permeability. FAAH-IN-5 produces near-complete blockade of TAMRA-FP labeling of human FAAH and MAGL, and produces significant blockade in homogenates. FAAH-IN-5 can be used in research related to FAAH-mediated diseases.
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- CAS. Nr.: 1338575-38-4
- Formel: C21H19N3O6S
- Molecular Weight:441.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 10.5 nM (FAAH), 283 nM (MAGL)[1]
In Vitro
FAAH-IN-5 exhibits a low artificial membrane permeability of 2.6 × 10−7 cm/s in PAMPA[1].
FAAH-IN-5 irreversibly inhibits human recombinant FAAH in a rapid dilution assay; it almost completely blocks TAMRA-FP labeling of human FAAH and MAGL, and significantly blocks labeling in rat eye homogenates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1338575-38-4
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Molecular Weight 441.46
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Formel C21H19N3O6S
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SMILES
O=C(N1CCN(CC1)S(=O)(C2=CC=C3C=CC=CC3=C2)=O)OC4=CC=C(C=C4)[N+]([O-])=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FAAH-IN-5 Related Classifications
HY-146341 Related Classifications
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