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Art. -Nr.: HY-114247

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FMAU

(Synonyms: D-FMAU)

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FMAU is a nucleoside analog and cell proliferation marker that can be phosphorylated by human thymidine kinase and subsequently incorporated into DNA. FMAU is applicable to research related to herpes simplex virus infection, various cancers, hepatitis B virus infection, and Epstein-Barr virus infection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.04%
CAS. Nr.: 69256-17-3
Formel: C₁₀H₁₃FN₂O₅
Molecular Weight:260.22

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

FMAU Chemical Structure

CAS. Nr.: 69256-17-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	>200 μM Compound: 13	The growth inhibition activity for the compound was evaluated in CEM cells. The growth inhibition activity for the compound was evaluated in CEM cells.	[PMID: 8709113]
HepG2 2.2.15	EC₅₀	0.1 μM Compound: 13	Anti hepatitis-B virus activity was evaluated in 2.2.15 cells. Anti hepatitis-B virus activity was evaluated in 2.2.15 cells.	[PMID: 8709113]
HepG2 2.2.15	IC₅₀	>200 μM Compound: 13	The growth inhibition activity for the compound was evaluated in 2.2.15 cells. The growth inhibition activity for the compound was evaluated in 2.2.15 cells.	[PMID: 8709113]
HL-60	IC₅₀	>1 mM Compound: 14	Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay	[PMID: 2033590]
HL-60	IC₅₀	>1 mM Compound: 14	Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay Inhibition of human promyelocytic leukemic cell (HL-60) trypan blue exclusion assay	[PMID: 2033590]
Vero	ED₅₀	0.018 μM Compound: 1a	Compound was tested for antiviral activity against Herpes simplex virus-1 (Strain F) in vero cells by plaque reduction assay. Compound was tested for antiviral activity against Herpes simplex virus-1 (Strain F) in vero cells by plaque reduction assay.	[PMID: 3001306]
Vero	ED₅₀	0.023 μM Compound: 1a	Compound was tested for antiviral activity against Herpes simplex virus-2 (Strain G) in vero cells by plaque reduction assay. Compound was tested for antiviral activity against Herpes simplex virus-2 (Strain G) in vero cells by plaque reduction assay.	[PMID: 3001306]

In Vitro

[¹⁸F]D-FMAU (20 μCi/2 mL; 15-240 min) exhibits significant time-dependent uptake in HSV1-TK gene-expressing MCA-TK cells, with a relative uptake ratio (MCA-TK/MCA) of 70 after 240 min of incubation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Radiolabeled FMAU accumulates in tumor tissue in a growth-rate dependent manner, with the highest uptake observed in rapidly growing colon carcinomas in rats^[1].
Radiolabeled D-FMAU achieves higher total tumor uptake than its L-isomer in human non-small cell lung cancer xenografts in nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 69256-17-3
Appearance Solid
Molecular Weight 260.22
Formel C₁₀H₁₃FN₂O₅
Color White to off-white
SMILES

O[C@H]1[C@H](F)[C@H](N(C(N2)=O)C=C(C)C2=O)O[C@@H]1CO
Synonyms

D-FMAU
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (480.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.8429 mL

19.2145 mL

38.4290 mL

5 mM

0.7686 mL

3.8429 mL

7.6858 mL

10 mM

0.3843 mL

1.9215 mL

3.8429 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Alauddin MM. Journey of 2'-deoxy-2'-fluoro-5-methyl-1-β-D-arabinofuranosyluracil (FMAU): from Antiviral Drug to PET Imaging Agent. Curr Med Chem. 2018;25(16):1867-1878. [Content Brief]

[2]. Nam Hyun Jo, et al. Synthesis and Evaluation of F-18 Labeled 2'-Deoxy-2'-fluoro-5-methyl-1-β-L-arabinofuranosyluracil (L-[18F]FMAU. Bull. Korean Chem. Soc. 2007, Vol. 28.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.8429 mL	19.2145 mL	38.4290 mL	96.0726 mL
	5 mM	0.7686 mL	3.8429 mL	7.6858 mL	19.2145 mL
	10 mM	0.3843 mL	1.9215 mL	3.8429 mL	9.6073 mL
	15 mM	0.2562 mL	1.2810 mL	2.5619 mL	6.4048 mL
	20 mM	0.1921 mL	0.9607 mL	1.9215 mL	4.8036 mL
	25 mM	0.1537 mL	0.7686 mL	1.5372 mL	3.8429 mL
	30 mM	0.1281 mL	0.6405 mL	1.2810 mL	3.2024 mL
	40 mM	0.0961 mL	0.4804 mL	0.9607 mL	2.4018 mL
	50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9215 mL
	60 mM	0.0640 mL	0.3202 mL	0.6405 mL	1.6012 mL
	80 mM	0.0480 mL	0.2402 mL	0.4804 mL	1.2009 mL
	100 mM	0.0384 mL	0.1921 mL	0.3843 mL	0.9607 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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FMAU

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

FMAU Related Classifications

HY-114247 Related Classifications