Ganglioside GM3
Based on 2 publication(s) in Google Scholar
Ganglioside GM3 is a precursor of a-, b-, and c-series gangliosides, interacts with transmembrane receptors such as the epidermal growth factor and insulin receptors, and regulates receptor functions by creating a specialized lipid environment. Ganglioside GM3 is synthesized by GM3 synthase and can be used for the research of hypercholesterolemia.
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- Reinheit : 96.63%
- CAS. Nr.: 124579-05-1
- Formel: C59H108N2O21
- Molecular Weight:1181.49
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ganglioside GM3
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Biologische Aktivität
Beschreibung
In Vitro
Ganglioside GM3, produced by addition of sialic acid to LacCer, is expressed mainly in adipose tissue and muscle in humans and mice, and liver and serum in humans. GM3 expression in adipocytes is induced by stimulation of the inflammatory cytokines TNF-α and IL-1β, derived from tissue macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 124579-05-1
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Appearance Solid
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Molecular Weight 1181.49
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Formel C59H108N2O21
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Color White to off-white
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SMILES
OC([C@@]1(O[C@@]([C@H](NC(C)=O)[C@@H](O)C1)([H])[C@H](O)[C@H](O)CO)O[C@@H]2[C@H]([C@@H](O[C@H](CO)[C@@H]2O)O[C@]3([H])[C@H](O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)[C@H]3O)CO)O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Hepatol Commun
2025 Sep 5;9(9):e0793. PMID: 40906894 -
Int J Mol Sci
Antidepressants Target the ST3GAL5-GM3 Lipid Pathway to Suppress Microglial Inflammation. [Abstract]2025 Oct 7;26(19):9733. PMID: 41096998
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (105.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Nihei W, et al. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains. J Lipid Res. 2018 Nov;59(11):2181-2187. [Content Brief]
[2]. Inokuchi JI, et al. Pathophysiological Significance of GM3 Ganglioside Molecular Species With a Particular Attention to the Metabolic Syndrome Focusing on Toll-Like Receptor 4 Binding. Front Mol Biosci. 2022 May 30;9:918346. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8464 mL | 4.2319 mL | 8.4639 mL | 21.1597 mL |
| 5 mM | 0.1693 mL | 0.8464 mL | 1.6928 mL | 4.2319 mL | |
| 10 mM | 0.0846 mL | 0.4232 mL | 0.8464 mL | 2.1160 mL | |
| 15 mM | 0.0564 mL | 0.2821 mL | 0.5643 mL | 1.4106 mL | |
| 20 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL | 1.0580 mL | |
| 25 mM | 0.0339 mL | 0.1693 mL | 0.3386 mL | 0.8464 mL | |
| 30 mM | 0.0282 mL | 0.1411 mL | 0.2821 mL | 0.7053 mL | |
| 40 mM | 0.0212 mL | 0.1058 mL | 0.2116 mL | 0.5290 mL | |
| 50 mM | 0.0169 mL | 0.0846 mL | 0.1693 mL | 0.4232 mL | |
| 60 mM | 0.0141 mL | 0.0705 mL | 0.1411 mL | 0.3527 mL | |
| 80 mM | 0.0106 mL | 0.0529 mL | 0.1058 mL | 0.2645 mL | |
| 100 mM | 0.0085 mL | 0.0423 mL | 0.0846 mL | 0.2116 mL |
Ganglioside GM3 Related Classifications
HY-114456 Related Classifications
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