Pot1a - protection of telomeres 1A Gene

Also Known as Pot1; 1500031H18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 101185

Summary

Enables single-stranded telomeric DNA binding activity. Acts upstream of or within chromosome organization. Located in chromosome, telomeric region. Part of nuclear telomere cap complex. Is expressed in several structures, including basisphenoid bone; brain; genitourinary system; musculature; and otic capsule. Human ortholog(s) of this gene implicated in familial melanoma and high grade glioma. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Apr 2022]

Pot1a Products (1)

mRNA Protein Name
NM_133931.5 NP_598692.1 protection of telomeres protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17053789 MGI
enables single-stranded telomeric DNA binding IDA
IDA: Inferred from direct assay
17053789 MGI
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
19854130 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within chromosome organization IGI
IGI: Inferred from genetic interaction
17053789 MGI
NOT involved in telomeric loop formation IGI
IGI: Inferred from genetic interaction
24120135 MGI
NOT involved in telomeric loop formation IMP
IMP: Inferred from mutant phenotype
24120135 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
23685356 MGI
part of nuclear telomere cap complex IDA
IDA: Inferred from direct assay
17053789 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protection of telomeres protein 1

  • POT1-like telomere end-binding protein

Pot1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Pot1 Q91WC1 Acd Mus musculus Q5EE38-1
CoIP
17632522
Intra
Pot1 Q91WC1 Tpp1 Mus musculus O89023
Y2H
17053789
Cross
Pot1 Q91WC1 ACD Homo sapiens Q96AP0
CoIP
17632522
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10804 POC1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10885 POT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10886 POTEA Human Pre-designed siRNA Set A Pre-designed Set / Unkown