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Dlg4 - discs large MAGUK scaffold protein 4 Gene

Also Known as Dlgh4; PSD95; SAP90; PSD-95; SAP90A

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13385

Summary

Enables ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within protein localization to synapse; regulation of long-term neuronal synaptic plasticity; and synaptic vesicle maturation. Located in several cellular components, including axon; postsynaptic density membrane; and synaptic vesicle. Is extrinsic component of cytoplasmic side of plasma membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Colocalizes with postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Dlg4 Products (6)

mRNA	Protein	Name
NM_001109752.1	NP_001103222.1	disks large homolog 4 isoform 2
NM_001370671.1	NP_001357600.1	disks large homolog 4 isoform 3
NM_001370672.1	NP_001357601.1	disks large homolog 4 isoform 4
NM_001370674.1	NP_001357603.1	disks large homolog 4 isoform 5
NM_001370675.1	NP_001357604.1	disks large homolog 4 isoform 6 precursor
NM_007864.3	NP_031890.1	disks large homolog 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	15207857	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9458051	MGI
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	16606358	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to potassium ion	IDA IDA: Inferred from direct assay	26609151	MGI
involved in dendritic spine morphogenesis	IDA IDA: Inferred from direct assay	20952458	MGI
involved in locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	20952458	MGI
involved in neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	20952458	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	17046693	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP IEP: Inferred from expression pattern	17046693	MGI
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	17046693	MGI
acts upstream of or within protein localization to synapse	IDA IDA: Inferred from direct assay	15978582	MGI
involved in regulation of grooming behavior	IMP IMP: Inferred from mutant phenotype	20952458	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IGI IGI: Inferred from genetic interaction	12427827	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	20952458	MGI
acts upstream of or within synaptic vesicle maturation	IDA IDA: Inferred from direct assay	15603741	MGI
acts upstream of or within synaptic vesicle maturation	IGI IGI: Inferred from genetic interaction	15603741	MGI
involved in vocalization behavior	IMP IMP: Inferred from mutant phenotype	20952458	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	15883194	MGI
located in cell junction	IDA IDA: Inferred from direct assay	21920314	MGI
located in cell periphery	IDA IDA: Inferred from direct assay	16828986	MGI
located in cerebellar mossy fiber	IDA IDA: Inferred from direct assay	23791195	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11483650	MGI
located in dendrite	IDA IDA: Inferred from direct assay	23395379	MGI
located in dendritic spine	IDA IDA: Inferred from direct assay	24464040	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16814779	MGI
located in excitatory synapse	IDA IDA: Inferred from direct assay	16980967	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17046693	MGI
located in glutamatergic synapse	IDA IDA: Inferred from direct assay	37261953	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	17046693	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17046693	MGI
located in juxtaparanode region of axon	IDA IDA: Inferred from direct assay	19109503	MGI
located in membrane	IDA IDA: Inferred from direct assay	15082773	MGI
located in neuron projection terminus	IDA IDA: Inferred from direct assay	12115694	MGI
located in neuron spine	IDA IDA: Inferred from direct assay	16606358	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11483650	MGI
located in postsynapse	IDA IDA: Inferred from direct assay	25709106	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	15317856	MGI
colocalizes with postsynaptic membrane	IDA IDA: Inferred from direct assay	15207857	MGI
located in synapse	IDA IDA: Inferred from direct assay	12972605	MGI
located in synapse	IMP IMP: Inferred from mutant phenotype	23424281	MGI
located in synaptic membrane	IDA IDA: Inferred from direct assay	23595732	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	16520334	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
disks large homolog 4	PSD-95 alpha 2b PSD-95 beta SAP-90 discs large homolog 4 discs, large homolog 4 postsynaptic density protein 95 synapse-associated protein 90

Dlg4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Dlg4	Q62108	Ablim1	Mus musculus	Q8K4G5	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Ablim1	Mus musculus	Q8K4G5	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Ablim1	Mus musculus	Q8K4G5	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Bait CoIP	19022416
Intra	Dlg4	Q62108	Gda	Mus musculus	Q9R111	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Kcna4	Mus musculus	Q61423	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Kcna4	Mus musculus	Q61423	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Neto1	Mus musculus	Q8R4I7	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Neto1	Mus musculus	Q8R4I7	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Neto1	Mus musculus	Q8R4I7	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Lrp2	Mus musculus	A2ARV4	Y2H	10827173
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Y2H	10827173
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Pull Down	10827173
Intra	Dlg4	Q62108	Lrp1	Mus musculus	Q91ZX7	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Ntrk2	Mus musculus	P15209	Anti Bait CoIP	23424281
Intra	Dlg4	Q62108	Dlg3	Mus musculus	P70175	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Dlg3	Mus musculus	P70175	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Mapk1	Mus musculus	P63085	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Mapk1	Mus musculus	P63085	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Bait CoIP	23424281
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Arc	Mus musculus	Q9WV31	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Nsf	Mus musculus	P46460	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Nsf	Mus musculus	P46460	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Nsf	Mus musculus	P46460	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	16601687
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	19240213
Intra	Dlg4	Q62108	Grin1	Mus musculus	P35438	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Crosslink	28713243
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin2a	Mus musculus	P35436	Anti Bait CoIP	28604739
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Pull Down	17950729
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	19243221
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	16710293
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	28604739
Intra	Dlg4	Q62108	Grin2b	Mus musculus	Q01097	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Dlg2	Mus musculus	Q91XM9	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Dlg2	Mus musculus	Q91XM9	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Dlg2	Mus musculus	Q91XM9	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Camk2a	Mus musculus	P11798	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Camk2a	Mus musculus	P11798	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Rac1	Mus musculus	P63001	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Rac1	Mus musculus	P63001	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Lrp8	Mus musculus	Q924X6	Anti Tag CoIP	16332682
Intra	Dlg4	Q62108	Dlg1	Mus musculus	Q811D0	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Dlg1	Mus musculus	Q811D0	Anti Bait CoIP	19455133
Intra	Dlg4	Q62108	Dlg1	Mus musculus	Q811D0	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Mdm2	Mus musculus	P23804	Anti Bait CoIP	23260144
Intra	Dlg4	Q62108	Sh3kbp1	Mus musculus	Q8R550	Density Sedimentation	20551902
Intra	Dlg4	Q62108	Pcdh10	Mus musculus	Q80TE2	Anti Bait CoIP	23260144
Intra	Dlg4	Q62108	Pcdh10	Mus musculus	Q80TE2	Confocal	23260144
Intra	Dlg4	Q62108	Sstr1	Mus musculus	P30873	Pull Down	17950729
Intra	Dlg4	Q62108	Sstr4	Mus musculus	P49660	Pull Down	17950729
Intra	Dlg4	Q62108	Baiap2	Mus musculus	Q8BKX1	Anti Bait CoIP	28671696
Intra	Dlg4	Q62108	Baiap2	Mus musculus	Q8BKX1	Anti Tag CoIP	19455133
Intra	Dlg4	Q62108	Nrcam	Mus musculus	Q810U4	Pull Down	16882004
Intra	Dlg4	Q62108	Nrcam	Mus musculus	Q810U4	Y2H Array	16882004
Intra	Dlg4	Q62108	Fzd7	Mus musculus	Q61090	Imaging	12067714
Intra	Dlg4	Q62108	Fzd7	Mus musculus	Q61090	Anti Tag CoIP	12067714
Intra	Dlg4	Q62108	Fzd7	Mus musculus	Q61090	Y2H Array	12067714
Intra	Dlg4	Q62108	Lrfn2	Mus musculus	Q80TG9	Anti Bait CoIP	16495444

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS28659	Dlg4 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS03799	DLG4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07700	LLGL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22138	Dlg4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dlg4	NCBI	NCBI:1742