Lrfn2 - leucine rich repeat and fibronectin type III domain containing 2 Gene

Also Known as SALM1; mKIAA1246; 5730420O05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70530

Summary

Involved in modulation of chemical synaptic transmission and regulation of postsynapse organization. Located in Schaffer collateral - CA1 synapse and cell surface. Is expressed in several structures, including central nervous system; esophagus; eye; male reproductive gland or organ; and trigeminal nerve. Used to study autism spectrum disorder. Orthologous to human LRFN2 (leucine rich repeat and fibronectin type III domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrfn2 Products (1)

mRNA Protein Name
NM_027452.3 NP_081728.2 leucine-rich repeat and fibronectin type-III domain-containing protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16495444 MGI
Biological Process GO Annotation Evidence References Source
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
28604739 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
28604739 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
28604739 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
28604739 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
28604739 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
28604739 MGI
located in cell surface IDA
IDA: Inferred from direct assay
16828986 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
31368584 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
31368584 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat and fibronectin type-III domain-containing protein 2

Lrfn2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lrfn2 Q80TG9 Dlg4 Mus musculus Q62108
Anti Tag CoIP
28604739
Intra
Lrfn2 Q80TG9 Dlg4 Mus musculus Q62108
Anti Tag CoIP
16495444
Intra
Lrfn2 Q80TG9 Dlg1 Mus musculus Q811D0
Anti Tag CoIP
16495444
Intra
Lrfn2 Q80TG9 Dlg1 Mus musculus Q811D0
Anti Bait CoIP
16495444
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07782 LRFN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22614 Lrfn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrfn2 NCBI NCBI:57497