Mc4r - melanocortin 4 receptor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25635

About Mc4r

Primary_assembly 18: 60,419,832-60,421,719 reverse strand.mRatBN7.2:CM026991.1

This gene has 1 transcript (splice variant), 231 orthologues, 18 paralogues and is associated with 44 phenotypes.

Summary

Enables Melanocortin Receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Located in nucleus and plasma membrane. Used to study obesity. Biomarker of obesity and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc4r Products (1)

mRNA Protein Name
NM_013099.3 NP_037231.1 melanocortin receptor 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables hormone binding IDA
IDA: Inferred from direct assay
21527895 RGD
enables melanocortin receptor activity IDA
IDA: Inferred from direct assay
17023527 RGD
enables melanocortin receptor activity IMP
IMP: Inferred from mutant phenotype
17023527 RGD
enables peptide hormone binding IDA
IDA: Inferred from direct assay
17023527 RGD
enables peptide hormone binding IMP
IMP: Inferred from mutant phenotype
17023527 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in diet induced thermogenesis IDA
IDA: Inferred from direct assay
14988515 RGD
involved in energy reserve metabolic process IDA
IDA: Inferred from direct assay
14988515 RGD
involved in feeding behavior IDA
IDA: Inferred from direct assay
14988515 RGD
involved in negative regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
20118207 RGD
involved in regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
21527895 RGD
involved in regulation of grooming behavior IMP
IMP: Inferred from mutant phenotype
21527895 RGD
involved in response to bisphenol A IEP
IEP: Inferred from expression pattern
35945320 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc4r Protein Structure

7tmA_MC4R

7tmA_MC4R: cd15353 (44 - 312)

7tmA_MC4R

7tmA_MC4R: cd15353 (45 - 71)

7tmA_MC4R

7tmA_MC4R: cd15353 (78 - 104)

7tmA_MC4R

7tmA_MC4R: cd15353 (121 - 151)

7tmA_MC4R

7tmA_MC4R: cd15353 (163 - 183)

7tmA_MC4R

7tmA_MC4R: cd15353 (188 - 217)

7tmA_MC4R

7tmA_MC4R: cd15353 (237 - 267)

7tmA_MC4R

7tmA_MC4R: cd15353 (280 - 305)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
Protein Preferred Names Protein Names

melanocortin receptor 4

  • MC4-R

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-19870 Setmelanotide Agonist 99.99% Yes
HY-18678A Bremelanotide Acetate Agonist 99.97% Unkown
HY-18678 Bremelanotide Agonist 99.94% Unkown
HY-P0060 Tetracosactide Agonist 99.46% Unkown
HY-P0060A Tetracosactide acetate Agonist 99.35% Unkown
HY-19870A Setmelanotide TFA Agonist / Unkown

Clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P0252 α-MSH Agonist 99.98% Phase 2
HY-153660 Bivamelagon Agonist 99.50% Phase 2
HY-10622 PF-00446687 free base Agonist 98.02% Phase 2
HY-118930 MK-0493 Agonist 99.43% Phase 2
HY-148349 PF-07258669 Antagonist 98.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (36)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P0267 Melanotan (MT)-II Agonist 99.97% Unkown
HY-10624 THIQ Agonist 98.48% Unkown
HY-P0227 SHU 9119 99.83% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 95.58% Unkown
HY-P0252A α-MSH TFA Agonist 98.97% Unkown
HY-P1215A HS024 TFA Antagonist 99.80% Unkown
HY-11030A SNT-207858 free base Antagonist 99.66% Unkown
HY-P2242A RO27-3225 TFA Agonist 98.65% Unkown
HY-110123 ML-00253764 hydrochloride Inhibitor 99.29% Unkown
HY-P1504 β-Melanocyte Stimulating Hormone (MSH), human Agonist 99.80% Unkown
HY-P0097 Nonapeptide-1 Antagonist 98.74% Unkown
HY-11029 SNT-207707 Inhibitor 99.54% Unkown
HY-P1504A β-Melanocyte Stimulating Hormone (MSH), human TFA Agonist 98.16% Unkown
HY-P1478 Adrenocorticotropic Hormone (ACTH) (4-10), human Agonist 99.18% Unkown
HY-19870C Setmelanotide monoacetate Agonist 99.81% Unkown
HY-P1213 JKC363 Antagonist 99.06% Unkown
HY-P1208 PG-931 Agonist 99.60% Unkown
HY-P4665 Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 Antagonist 98.14% Unkown
HY-P11469 PG-901 Modulator 99.35% Unkown
HY-P1216A HS014 TFA Antagonist 98.84% Unkown
HY-P1215 HS024 Antagonist / Unkown
HY-P3561 Agouti-related Protein (AGRP) (83-132) Amide (human) Antagonist / Unkown
HY-153660A Bivamelagon hydrochloride Agonist / Unkown
HY-P10985 CTX-1211 Agonist / Unkown
HY-P1216 HS014 Antagonist / Unkown
HY-10623 PF-00446687 hydrochloride Agonist / Unkown
HY-P1213A JKC363 TFA Antagonist / Unkown
HY-P0252B α-MSH free acid Agonist / Unkown
HY-W559510 MC4R antagonist-3 Antagonist / Unkown
HY-P1208A PG-931 TFA Agonist / Unkown
HY-111131 RY764 Agonist / Unkown
HY-183106 MC4R antagonist-2 Antagonist / Unkown
HY-11073 MK-0489 Agonist / Unkown
HY-P0267A Melanotan (MT)-II acetate Agonist / Unkown
HY-125055A CD08108 Agonist / Unkown
HY-182773 MC4R Antagonist-1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc4r NCBI NCBI:4160