1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. SNT-207858 free base

SNT-207858 free base 

Cat. No.: HY-11030A
Handling Instructions

SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207858 free base Chemical Structure

SNT-207858 free base Chemical Structure

CAS No. : 1104662-66-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 610 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

IC50 & Target

MC-4 receptor[1]

In Vitro

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].

In Vivo

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].

Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1]
Dosage: 30 mg/kg
Administration: Oral administration; once daily; 15 days
Result: Significantly reduced the tumor induced weight loss.
Molecular Weight

616.62

Formula

C₃₂H₄₃Cl₂N₅O₃

CAS No.

1104662-66-9

SMILES

O=C(N1CCCC1)N[[email protected]](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[[email protected]](N5CCCC5)CC)CC3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (202.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6217 mL 8.1087 mL 16.2174 mL
5 mM 0.3243 mL 1.6217 mL 3.2435 mL
10 mM 0.1622 mL 0.8109 mL 1.6217 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SNT-207858SNT207858SNT 207858Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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SNT-207858 free base
Cat. No.:
HY-11030A
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