1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. SNT-207858

SNT-207858 

Cat. No.: HY-11030
Handling Instructions

SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207858 Chemical Structure

SNT-207858 Chemical Structure

CAS No. : 1104080-42-3

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Description

SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1].

IC50 & Target

IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]

In Vitro

SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].

In Vivo

SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].

Animal Model: Mice with C26 adenocarcinoma-induced cachexia model[1]
Dosage: 30 mg/kg
Administration: Oral administration; once daily; 15 days
Result: Significantly reduced the tumor induced weight loss.
Molecular Weight

689.54

Formula

C₃₂H₄₅Cl₄N₅O₃

CAS No.

1104080-42-3

SMILES

[H]Cl.O=C(N1CCCC1)N[[email protected]](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[[email protected]](N5CCCC5)CC)CC3)=O.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SNT-207858SNT207858SNT 207858Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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