SNT-207858
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
For research use only. We do not sell to patients.
- CAS No.: 1104080-42-3
- Formula: C32H45Cl4N5O3
- Molecular Weight:689.54
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-19870
SetmelanotideMC4R Agonist -
HY-107139
JNJ-10229570Melanocortin Receptor Antagonist -
HY-11029
SNT-207707MC-4 Receptor Antagonist -
HY-107627
MCL0020MC4 Receptor Antagonist -
HY-110123
ML-00253764 hydrochlorideMC4R Antagonist -
HY-P1726
MSG606MC1R Antagonist -
HY-10624
THIQMC4R Agonist -
HY-109114
DersimelagonMC1R Agonist -
HY-P0227
SHU 9119MC3/4R Antagonist -
HY-11030A
SNT-207858 free baseMelanocortin Receptor Antagonist -
HY-18678
BremelanotideMelanocortin Receptor Agonist -
HY-18678A
Bremelanotide AcetateMelanocortin Receptor Agonist
Biological Activity
Description
IC50 & Target
IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]
In Vitro
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Mice with C26 adenocarcinoma-induced cachexia model[1]
-
Dosage:30 mg/kg
-
Administration:Oral administration; once daily; 15 days
-
Result:Significantly reduced the tumor induced weight loss.
Chemical Information
-
CAS No. 1104080-42-3
-
Molecular Weight 689.54
-
Formula C32H45Cl4N5O3
-
SMILES
[H]Cl.O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SNT-207858 Related Classifications
HY-11030 Related Classifications
Powered by Bioz