1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor

SNT-207858 

Cat. No.: HY-11030
Handling Instructions

SNT-207858 is a selective and orally available melanocortin MC-4 receptor antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. SNT-207858 has an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

For research use only. We do not sell to patients.

SNT-207858 Chemical Structure

SNT-207858 Chemical Structure

CAS No. : 1104080-42-3

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

SNT-207858 is a selective and orally available melanocortin MC-4 receptor antagonist with a 170-fold selectivity vs. MC-3 and a 40-fold selectivity versus MC-5. SNT-207858 has an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor.

IC50 & Target

IC50: 8 nM (binding, MC-4), 5 nM (function, MC-4)[1]

In Vivo

Subcutaneous injection or oral treatment by gavage of SNT-207858 distinctly increase food intake in healthy mice. In mice subcutaneously implanted with C26 adenocarcinoma cells, repeated oral administration (starting the day after tumor implantation) of SNT-207858 almost completely prevents tumor induced weight loss, and diminished loss of lean body mass and fat mass[1].

References
Animal Administration
[1]

Mice[1]

Twelve weeks old male CD-1 mice are dosed by gavage with SNT207858 at 60 mg/kg. At 1, 3, and 6 hrs post-dose, mice are euthanized and blood is collected[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

689.54

Formula

C₃₂H₄₅Cl₄N₅O₃

CAS No.

1104080-42-3

SMILES

[H]Cl.O=C(N1CCCC1)N[[email protected]](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[[email protected]](N5CCCC5)CC)CC3)=O.[H]Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SNT-207858
Cat. No.:
HY-11030
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SNT-207858

Cat. No.: HY-11030