SNT-207858
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor.
For research use only. We do not sell to patients.
- CAS No.: 1104080-42-3
- Formula: C32H45Cl4N5O3
- Molecular Weight:689.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1]
SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with C26 adenocarcinoma-induced cachexia model[1]
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Dosage:30 mg/kg
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Administration:Oral administration; once daily; 15 days
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Result:Significantly reduced the tumor induced weight loss.
Chemical Information
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CAS No. 1104080-42-3
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Molecular Weight 689.54
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Formula C32H45Cl4N5O3
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SMILES
[H]Cl.O=C(N1CCCC1)N[C@H](CC2=CC=C(Cl)C=C2Cl)C(N3CCC(C4=NC=CC=C4OC[C@H](N5CCCC5)CC)CC3)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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