1. GPCR/G Protein Neuronal Signaling
  2. Melanocortin Receptor
  3. MK-0493


Cat. No.: HY-118930 Purity: 99.02%
COA Handling Instructions

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

For research use only. We do not sell to patients.

MK-0493 Chemical Structure

MK-0493 Chemical Structure

CAS No. : 455956-93-1

Size Price Stock Quantity
5 mg USD 1080 In-stock
10 mg USD 1700 In-stock
25 mg USD 3450 In-stock
50 mg USD 5550 In-stock
100 mg USD 8900 Get quote
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].

IC50 & Target



In Vivo

MK-0493 dose-dependently increases electrically evoked increases in ICP[2].
MK-0493 is shown to promote robust weight loss activity following oral administration in preclinical animal models, suggesting the drug can access the target site in the hypothalamus[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (183.12 mM; Need ultrasonic)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8312 mL 9.1560 mL 18.3120 mL
5 mM 0.3662 mL 1.8312 mL 3.6624 mL
10 mM 0.1831 mL 0.9156 mL 1.8312 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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MK-0493 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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