2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. MK-0493

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

For research use only. We do not sell to patients.

MK-0493 Chemical Structure

MK-0493 Chemical Structure

CAS No. : 455956-93-1

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1 mg USD 195 In-stock
5 mg USD 430 In-stock
10 mg USD 690 In-stock
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Based on 1 publication(s) in Google Scholar

MK-0493 Related Antibodies

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Description

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].

IC50 & Target

MC4R

 

In Vivo

MK-0493 dose-dependently increases electrically evoked increases in ICP[2].
MK-0493 is shown to promote robust weight loss activity following oral administration in preclinical animal models, suggesting the drug can access the target site in the hypothalamus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

546.09

Formula

C30H38ClF2N3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(N[C@@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([C@@H]3CN(C[C@H]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (183.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8312 mL 9.1560 mL 18.3120 mL
5 mM 0.3662 mL 1.8312 mL 3.6624 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8312 mL 9.1560 mL 18.3120 mL 45.7800 mL
5 mM 0.3662 mL 1.8312 mL 3.6624 mL 9.1560 mL
10 mM 0.1831 mL 0.9156 mL 1.8312 mL 4.5780 mL
15 mM 0.1221 mL 0.6104 mL 1.2208 mL 3.0520 mL
20 mM 0.0916 mL 0.4578 mL 0.9156 mL 2.2890 mL
25 mM 0.0732 mL 0.3662 mL 0.7325 mL 1.8312 mL
30 mM 0.0610 mL 0.3052 mL 0.6104 mL 1.5260 mL
40 mM 0.0458 mL 0.2289 mL 0.4578 mL 1.1445 mL
50 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.9156 mL
60 mM 0.0305 mL 0.1526 mL 0.3052 mL 0.7630 mL
80 mM 0.0229 mL 0.1144 mL 0.2289 mL 0.5722 mL
100 mM 0.0183 mL 0.0916 mL 0.1831 mL 0.4578 mL
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MK-0493 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-0493455956-93-1MK0493MK 0493Melanocortin ReceptorMC ReceptorErectiledysfunctionobesityInhibitorinhibitorinhibit

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