1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. MK-0493

MK-0493 

Cat. No.: HY-118930
Handling Instructions

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake.

For research use only. We do not sell to patients.

MK-0493 Chemical Structure

MK-0493 Chemical Structure

CAS No. : 455956-93-1

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Description

MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake[1].

In Vivo

MK-0493 dose-dependently increases electrically evoked increases in ICP[2].
MK-0493 is shown to promote robust weight loss activity following oral administration in preclinical animal models, suggesting the drug can access the target site in the hypothalamus[3].

Molecular Weight

546.09

Formula

C₃₀H₃₈ClF₂N₃O₂

CAS No.

455956-93-1

SMILES

CC(N[[email protected]@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([[email protected]@H]3CN(C[[email protected]]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MK-0493MK0493MK 0493Melanocortin ReceptorMC ReceptorErectiledysfunctionobesityInhibitorinhibitorinhibit

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MK-0493
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HY-118930
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