455956-93-1
455956-93-1
Chemical Structure
MK-0493
- CAS No.: 455956-93-1
- Formula:C30H38ClF2N3O2
- Molecular Weight:546.09
IUPAC Name: N-((S)-1-(2-(1-((3S,4R)-1-(tert-butyl)-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)piperidin-4-yl)-5-chlorophenyl)ethyl)acetamide
InChIKey: ZCWVNCMFYHPHCX-RHLLTPQKSA-N
SMILES: CC(N[C@@H](C)C1=CC(Cl)=CC=C1C2CCN(CC2)C([C@@H]3CN(C[C@H]3C4=CC=C(C=C4F)F)C(C)(C)C)=O)=O
Biological Activity: MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity[1][2].
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MK-0493 | 98.19% | MK-0493 is an orally active melanocortin-4 receptor (MC4R) agonist. MK-0493 reduces food intake, suppresses weight gain, elevates blood pressure at high doses, and exhibits preclinical erectile regulatory activity. MK-0493 can be used in research related to obesity. | ||||||||||||||||||||
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References
- [1]. Krishna R, etal. Potent and selective agonism of the melanocortin receptor 4 with MK-0493 does not induce weight loss in obese human subjects: energy intake predicts lack of weight loss efficacy. Clin Pharmacol Ther. 2009 Dec;86(6):659-66. [Content Brief]
- [2]. Krishna R, et al. Lack of erectogenic activity of a novel selective melanocortin-4 receptor agonist in a clinical experimental model. J Clin Pharmacol. 2008 Oct;48(10):1237-41. [Content Brief]
