Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 306782

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of glutamatergic synaptic transmission; positive regulation of macrophage differentiation; and positive regulation of protein serine/threonine kinase activity. Located in several cellular components, including dendrite; microtubule; and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like Orphan Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ror2 Products (1)

mRNA Protein Name
NM_001107339.1 NP_001100809.1 tyrosine-protein kinase transmembrane receptor ROR2 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Verweise Source
involved in astrocyte development IDA
IDA: Inferred from direct assay
15095375 RGD
involved in bone mineralization IEP
IEP: Inferred from expression pattern
23337931 RGD
involved in macrophage migration IMP
IMP: Inferred from mutant phenotype
25749876 RGD
involved in male genitalia development IEP
IEP: Inferred from expression pattern
23895974 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26311509 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26311509 RGD
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
25825749 RGD
involved in positive regulation of macrophage differentiation IMP
IMP: Inferred from mutant phenotype
25749876 RGD
involved in positive regulation of protein kinase C activity IMP
IMP: Inferred from mutant phenotype
25825749 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
25825749 RGD
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
26003414 RGD
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
26003414 RGD
involved in regulation of synaptic signaling by nitric oxide IDA
IDA: Inferred from direct assay
26311509 RGD
involved in regulation of synaptic signaling by nitric oxide IMP
IMP: Inferred from mutant phenotype
26311509 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
15095375 RGD
located in dendrite IDA
IDA: Inferred from direct assay
25825749 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26003414 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26003414 RGD
located in microtubule IDA
IDA: Inferred from direct assay
15095375 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
25825749 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
26003414 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase transmembrane receptor ROR2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-145626 Ozuriftamab 99.73% Phase 2
HY-145627 Ozuriftamab vedotin Inhibitor 99.64% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-186189 OPA-S-S-alkyne / Unkown
HY-RS12125 ROR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12126 RORA Human Pre-designed siRNA Set A / Unkown
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / Unkown
HY-RS17495 Ror2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23952 Ror2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ror2 NCBI NCBI:4920