DDI1 - DNA damage inducible 1 homolog 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 414301

About DDI1

This gene has 1 transcript (splice variant), 188 orthologues and 4 paralogues.

Summary

Predicted to enable aspartic-type endopeptidase activity. Involved in several processes, including cellular response to hydroxyurea; proteasomal protein catabolic process; and regulation of DNA stability. [provided by Alliance of Genome Resources, Apr 2022]

DDI1 Products (1)

mRNA	Protein	Name
NM_001001711.3	NP_001001711.1	protein DDI1 homolog 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of DNA stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDI1 Protein Structure

ubiquitin

Asp_protease

0
100
200
300
396 a.a.

Protein Preferred Names	Protein Names
protein DDI1 homolog 1	DDI1, DNA-damage inducible 1, homolog 1

DDI1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DDI1	Q8WTU0	RPP25	Homo sapiens	Q9BUL9	Validated Y2H	32296183
Intra	DDI1	Q8WTU0	UBE2K	Homo sapiens	P61086	Y2H Prey Pooling	25416956
Intra	DDI1	Q8WTU0	UBE2K	Homo sapiens	P61086	Y2H Array	25416956
Intra	DDI1	Q8WTU0	CYGB	Homo sapiens	Q8WWM9	Validated Y2H	32296183
Intra	DDI1	Q8WTU0	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	DDI1	Q8WTU0	KLHL42	Homo sapiens	Q9P2K6	Validated Y2H	32296183
Intra	DDI1	Q8WTU0	KLHL42	Homo sapiens	Q9P2K6	Y2H Array	25416956
Intra	DDI1	Q8WTU0	CCL28	Homo sapiens	Q9NRJ3	Validated Y2H	25416956
Intra	DDI1	Q8WTU0	CCL28	Homo sapiens	Q9NRJ3	Y2H Array	25416956
Intra	DDI1	Q8WTU0	CCL28	Homo sapiens	Q9NRJ3	Y2H Prey Pooling	25416956
Intra	DDI1	Q8WTU0	CCL28	Homo sapiens	Q9NRJ3	Validated Y2H	32296183
Intra	DDI1	Q8WTU0	TEKT3	Homo sapiens	Q9BXF9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ruijs-Aalfs Syndrome	Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome RJALS
Ngly1-Deficiency	Deficiency Of N-Glycanase 1 Ngly1-Cddg Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome Ngly1 Deficiency Congenital Disorder Of Deglycosylation Congenital Disorder Of Glycosylation Type Iv Congenital Disorder Of Deglycosylation Cddg Congenital Disorder Of Glycosylation Type Iv Cdg1v
Kenny-Caffey Syndrome, Type 2	KCS2 Kenny-Caffey Syndrome Type 2 Autosomal Dominant Kenny-Caffey Syndrome Kenny Syndrome Dwarfism, Cortical Thickening Of Tubular Bones, And Transient Hypocalcemia Dwarfism, Cortical Thickening Of Tubular Bones And Transient Hypocalcemia Kenny-Caffey Syndrome, Autosomal Dominant Kenny-Caffey Syndrome 2 Dwarfism With Cortical Thickening Of Tubular Bones And Transient Hypocalcemia Kenny-Caffey Syndrome
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Median Arcuate Ligament Syndrome	Celiac Artery Compression Syndrome Dunbar Syndrome Mals Harjola-Marable Syndrome Marable'S Syndrome Celiac Axis Syndrome
Childhood Germ Cell Cancer	Pediatric Germ Cell Tumor Paediatric Germ Cell Cancer Paediatric Germ Cell Neoplasm Pediatric Germ Cell Cancer Pediatric Germ Cell Neoplasm
Kenny-Caffey Syndrome	Kenny Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03611	DDI1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DDI1	VGNC	VGNC:27945
Mus musculus	DDI1	MGD	MGI:1919079
Rattus norvegicus	DDI1	RGD	RGD:1559430
Canis familiaris	DDI1	VGNC	VGNC:39834
Felis catus	DDI1	VGNC	VGNC:105842
Macaca mulatta	DDI1	VGNC	VGNC:100923
Others	DDI1	NCBI