GCFC2 - GC-rich sequence DNA-binding factor 2 Gene

Also Known as GCF; TCF9; DNABF; C2orf3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6936

About GCFC2

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:75,662,705-75,713,122 (from NCBI)

This gene has 11 transcripts (splice variants), 242 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 5.0), testis (RPKM 4.3) and 25 other tissues.

Summary

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]

GCFC2 Products (4)

mRNA Protein Name
NM_001201334.2 NP_001188263.1 intron Large complex component GCFC2 isoform 2
NM_001201335.2 NP_001188264.1 intron Large complex component GCFC2 isoform 3
NM_001410845.1 NP_001397774.1 intron Large complex component GCFC2 isoform 4
NM_003203.5 NP_003194.3 intron Large complex component GCFC2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
24304693 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in spliceosomal complex assembly IMP
IMP: Inferred from mutant phenotype
24304693 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of U2-type post-mRNA release spliceosomal complex IDA
IDA: Inferred from direct assay
24304693 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
24304693 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24304693 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCFC2 Protein Structure

GCFC

GCFC: GC-rich sequence DNA-binding factor-like protein (468 - 681)

  • 0
  • 200
  • 400
  • 600
  • 781 a.a.
Protein Preferred Names Protein Names

intron Large complex component GCFC2

  • GC binding factor

GCFC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9
Anti Tag CoIP
24304693
Intra
GCFC2 P16383 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyslexia
Reading Disorder

  • Specific Reading Disorder

  • Reading

  • Dyslexia

  • Developmental Reading Disorder
Learning Disability

  • Learning Disabilities

  • Learning Disorders

  • Academic Skill Disorder

  • Learning Disorder
Specific Language Impairment

  • Language Impairment, Specific
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05322 GCFC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GCFC2 VGNC VGNC:62490
Mus musculus GCFC2 MGD MGI:2141656
Rattus norvegicus GCFC2 RGD RGD:1304792
Canis familiaris GCFC2 VGNC VGNC:41142
Bos taurus GCFC2 VGNC VGNC:29283
Macaca mulatta GCFC2 VGNC VGNC:72715
Others GCFC2 NCBI