PTGES2 - prostaglandin E synthase 2 Gene

Also Known as GBF1; GBF-1; PGES2; C9orf15; mPGES-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80142

About PTGES2

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,120,693-128,128,440 (from NCBI)

This gene has 21 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in heart (RPKM 13.3), kidney (RPKM 10.1) and 25 other tissues.

Summary

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

PTGES2 Products (3)

mRNA Protein Name
NM_001256335.2 NP_001243264.1 prostaglandin E synthase 2 isoform 2
NM_025072.7 NP_079348.1 prostaglandin E synthase 2 isoform 1
NM_198938.3 NP_945176.1 prostaglandin E synthase 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables lyase activity IDA
IDA: Inferred from direct assay
17585783 GOA
enables prostaglandin-E synthase activity IDA
IDA: Inferred from direct assay
12804604 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in lipid metabolic process IDA
IDA: Inferred from direct assay
17585783 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
12835322 GOA
located in cytosol IDA
IDA: Inferred from direct assay
12835322 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGES2 Protein Structure

GST_N_3

GST_N_3: Glutathione S-transferase, N-terminal domain (104 - 172)

GST_C_3

GST_C_3: Glutathione S-transferase, C-terminal domain (242 - 368)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

prostaglandin E synthase 2

  • GATE-binding factor 1

PTGES2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PTGES2 Q9H7Z7 CFAP141 Homo sapiens Q5VU69
Y2H Prey Pooling
25416956
Intra
PTGES2 Q9H7Z7 CFAP141 Homo sapiens Q5VU69
Validated Y2H
25416956
Cross
PTGES2 Q9H7Z7 P0DTD1-PRO_0000449625 SARS-CoV-2 P0DTD1-PRO_0000449625
Y2H Array
36217030
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11380 PTGES2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19804 Ptges2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26300 Ptges2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTGES2 VGNC VGNC:45146
Felis catus PTGES2 VGNC VGNC:64428
Macaca mulatta PTGES2 VGNC VGNC:76505
Bos taurus PTGES2 VGNC VGNC:33506
Rattus norvegicus PTGES2 RGD RGD:1310836
Mus musculus PTGES2 MGD MGI:1917592
Others PTGES2 NCBI