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Art. -Nr.: HY-185334

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GNE-3565

GNE-3565 is an arylsulfonamide class Na_V1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain.

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CAS. Nr.: 2222537-72-4
Formel: C₂₅H₂₆ClF₄N₅O₂S
Molecular Weight:572.02

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

GNE-3565 Chemical Structure

CAS. Nr.: 2222537-72-4

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

GNE-3565 is an arylsulfonamide class Na_V1.7 inhibitor with subnanomolar channel blockage and mixed subtype selectivity.GNE-3565 can be used for the research of pain^[1].

Alle Sodium Channel Isoform-spezifische Produkte anzeigen :

In Vitro

GNE-3565 (50 μM; 10 min at 22 °C) binds to the VSD4 domain of the VSD4-NaV1.7-NaVPas chimeric channel in a pose similar to the arylsulfonamide inhibitor GX-936, forming key interactions with the R4 gating charge and subtype-selectivity residues Tyr1537 and Trp1538^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2222537-72-4
Molecular Weight 572.02
Formel C₂₅H₂₆ClF₄N₅O₂S
SMILES

CN(C)[C@@H](C[C@@H](C1=CC(C(F)(F)F)=CC=C1)CC2)[C@H]2NC3=C(C=C(C(F)=C3)S(NC4=NC=NC=C4)(=O)=O)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kschonsak M, et al. Cryo-EM reveals an unprecedented binding site for Na_V1.7 inhibitors enabling rational design of potent hybrid inhibitors. Elife. 2023;12:e84151. Published 2023 Mar 28. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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GNE-3565

Alle Sodium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

GNE-3565 Related Classifications

HY-185334 Related Classifications