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Art. -Nr.: HY-P2995

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Hemoglobin, Bovine

Name: Hemoglobin, Bovine
Brand: MedChemExpress
SKU: HY-P2995
Price: 25.00 USD
Availability: InStock
Rating: 5 (4 reviews)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Hemoglobin, Bovine is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin, Bovine consits of heme, which binds to oxygen. Hemoglobin, Bovine also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin, Bovine absorbs unneeded oxygen in tissues, as an antioxidant.

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CAS. Nr.: 9008-02-0

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Hemoglobin, Bovine Chemical Structure

CAS. Nr.: 9008-02-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Heme Oxygenase (HO) Isoform-spezifische Produkte anzeigen :

HO-1
HO-2

In Vitro

Hemoglobin, Bovine (1-50 μM, 6 h) increases α1-microglobulin and reactive oxygen species in HepG2 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hemoglobin, Bovine (300 mg/k, i.v. at 16 h before LPS) provides protection against LPS induced lethal endotoxemia in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS induced endotoxemia rat model^[2]
Dosage:

300 mg/kg
Administration:

i.v., at 16 h before LPS treatment (40 mg/kg, i.v,)
Result:

Increased rat survival.
Showed significant attenuation of neutrophil alveolitis ( > 80 %) at 24 h after LPS injection.
Increased HO-1 expression and activity in rat lung.

Chemical Information

CAS. Nr. 9008-02-0
Appearance Solid
Color Brown to reddish brown
SMILES

[Hemoglobin, Bovine]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All Flow CytometryWBBio/Physico-chemical AssayCell Imaging/Staining

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Journal Impact Factor

Int J Biol Macromol

Dynamic catalytic domain plasticity governs substrate specificity in industrial serine proteases: Structural and functional implications. [Abstract]

2025 Oct 17;331(Pt 1):148374. PMID: 41110577
Photonics Res

2025.
Antioxid Redox Signal

Hydrogen Attenuates Oxidative Damage via NRF2-Mediated Mitophagy after Subarachnoid Hemorrhage. [Abstract]

2025 Dec 26. PMID: 41468154

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Flow cytometry by Annexin V-APC:7-AAD staining and analysis of apoptosis rate. Hemoglobin (HB) (30 μM; 24 h) treatment increased the percentage of apoptotic cells in HT22 mouse hippocampal neuronal cells, as indicated by higher Annexin V-APC+/7-AAD-cells.

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Western blotting images and quantitative data of relative expression levels of 4-hydroxynonenal (4-HNE), BAX, BCL-2, and cleaved caspase-3 were presented. Hemoglobin (HB) (30 μM; 24 h) treatment upregulated levels of 4-hydroxynonenal (4-HNE), proapoptotic proteins Bax and cleaved caspase-3 while downregulated the antiapoptotic protein BCL-2.

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Hemoglobin (HB) (30 μM; 24 h) exposure led to marked increases in MDA, hydrogen peroxide and decreased superoxide dismutase (SOD) activity.

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Hemoglobin (HB) (30 μM; 24 h) caused the mitochondrial outer membranes to become denser, with some showing rupture, and reduced or eliminated cristae, and induced vacuolization and the occasional formation of autophagic vesicles.

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Western blotting images and quantitative data of relative expression levels of p62, PINK1, PARKIN, and LC3II/I were presented. Hemoglobin (HB) (30 μM; 24 h) increased the LC3-II/I ratio and the levels of PINK1, p62, and Parkin, indicating impaired autophagic flux and enhanced mitophagy activity.
Int Immunopharmacol

The mechanism study of isoorientin regulating neuroinflammation after subarachnoid hemorrhage through AKT/GSK3β. [Abstract]

2026 Apr 1:174:116299. PMID: 41671619

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ahmed MH, Ghatge MS, Safo MK. Hemoglobin: Structure, Function and Allostery. Subcell Biochem. 2020;94:345-382. [Content Brief]

[2]. Ciaccio C, et al. Role of hemoglobin structural-functional relationships in oxygen transport. Mol Aspects Med. 2022 Apr;84:101022. [Content Brief]

[3]. Otterbein L, et al. Hemoglobin provides protection against lethal endotoxemia in rats: the role of heme oxygenase-1. Am J Respir Cell Mol Biol. 1995 Nov;13(5):595-601. [Content Brief]

[4]. Olsson MG, et al. Up-regulation of alpha1-microglobulin by hemoglobin and reactive oxygen species in hepatoma and blood cell lines. Free Radic Biol Med. 2007 Mar 15;42(6):842-51. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Hemoglobin, Bovine

4 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Reinheit & Dokumentation
Verweise

1/16
1/16

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Flow cytometry by Annexin V-APC:7-AAD staining and analysis of apoptosis rate. Hemoglobin (HB) (30 μM; 24 h) treatment increased the percentage of apoptotic cells in HT22 mouse hippocampal neuronal cells, as indicated by higher Annexin V-APC+/7-AAD-cells.
1/16

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Western blotting images and quantitative data of relative expression levels of 4-hydroxynonenal (4-HNE), BAX, BCL-2, and cleaved caspase-3 were presented. Hemoglobin (HB) (30 μM; 24 h) treatment upregulated levels of 4-hydroxynonenal (4-HNE), proapoptotic proteins Bax and cleaved caspase-3 while downregulated the antiapoptotic protein BCL-2.
1/16

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Hemoglobin (HB) (30 μM; 24 h) exposure led to marked increases in MDA, hydrogen peroxide and decreased superoxide dismutase (SOD) activity.
1/16

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Hemoglobin (HB) (30 μM; 24 h) caused the mitochondrial outer membranes to become denser, with some showing rupture, and reduced or eliminated cristae, and induced vacuolization and the occasional formation of autophagic vesicles.
1/16

Hemoglobin, Bovine purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2025 Dec 26. [Abstract]

Customer Validation
Western blotting images and quantitative data of relative expression levels of p62, PINK1, PARKIN, and LC3II/I were presented. Hemoglobin (HB) (30 μM; 24 h) increased the LC3-II/I ratio and the levels of PINK1, p62, and Parkin, indicating impaired autophagic flux and enhanced mitophagy activity.

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Hemoglobin, Bovine

Publications Citing Use of MedChemExpress (MCE) Hemoglobin, Bovine

Alle Heme Oxygenase (HO) Isoform-spezifische Produkte anzeigen