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Art. -Nr.: HY-N10304

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Isodispar B

Isodispar B is an anticancer agent that inhibits the proliferation of nasopharyngeal carcinoma and breast cancer cells and induces cell apoptosis. Isodispar B is cytotoxic to a wide range of cancer cell lines.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 98192-64-4
Formel: C₂₀H₁₈O₅
Molecular Weight:338.35

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Isodispar B Chemical Structure

CAS. Nr.: 98192-64-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
KB	IC₅₀	4 μg/mL Compound: 23	Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay Cytotoxicity against human KB cells assessed as inhibition of cell growth incubated for 72 hrs by neutral red dye based colorimetric assay	[PMID: 27494166]
MCF7	GI₅₀	1.5 μg/mL Compound: 13	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 15787438]
NCI-H460	GI₅₀	1.9 μg/mL Compound: 13	Cytotoxicity against human H460 cells Cytotoxicity against human H460 cells	[PMID: 15787438]
SF-268	GI₅₀	1.8 μg/mL Compound: 13	Cytotoxicity against human SF268 cells Cytotoxicity against human SF268 cells	[PMID: 15787438]

In Vitro

Isodispar B (compound 1) (0-100 μM; 72 h) exerts a broad spectrum of anti-cancer activity to inhibit cell proliferation with IC₅₀s of 3.84-56.73 μM^[1].
Isodispar B (1 μM and 10 μM; 3 d) induces apoptosis on nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Nasopharyngeal cancer cells (TW01, CNE1, HK1, and SUNE1) and noncancerous nasopharyngeal cells (NP460)
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Showed cytotoxicity and inhibited cell viability with IC50s of 3.84 μM (SUNE1), 11.49 μM (TW01), 9.74 μM (CNE1), 5.58 μM (HK1), 56.73 μM (HCC38), 52.69 μM (MDA-MB-231), 52.75 μM (MDA-ME-468), and 54.85 μM (SKBR3), respectively.

Chemical Information

CAS. Nr. 98192-64-4
Molecular Weight 338.35
Formel C₂₀H₁₈O₅
SMILES

O=C1C=C(C2=CC=CC=C2)C3=C(O)C=C(O)C(C(CC(C)C)=O)=C3O1
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lim C K, et al. In vitro cytotoxic activity of isolated compounds from Malaysian Calophyllum species[J]. Medicinal Chemistry Research, 2016, 25(8): 1686-1694.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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