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Art. -Nr.: HY-159627

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Met-AMS

Met-AMS (Compound 50) is a sulfonamide analog of methionyl-adenylate (Met-AMP) and an inhibitor of isoleucyl-tRNA synthetase (IleRS) with an IC₅₀ of 7 nM.

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CAS. Nr.: 560071-70-7
Formel: C₁₅H₂₃N₇O₇S₂
Molecular Weight:477.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Met-AMS Chemical Structure

CAS. Nr.: 560071-70-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Met-AMS (Compound 50) is a sulfonamide analog of methionyl-adenylate (Met-AMP) and an inhibitor of isoleucyl-tRNA synthetase (IleRS) with an IC₅₀ of 7 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	0.5 μM Compound: MetSA	Immunosuppressive activity against human PBMC assessed as inhibition of allogenic mixed lymphocyte reaction Immunosuppressive activity against human PBMC assessed as inhibition of allogenic mixed lymphocyte reaction	[PMID: 18438987]

Chemical Information

CAS. Nr. 560071-70-7
Molecular Weight 477.52
Formel C₁₅H₂₃N₇O₇S₂
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C(N)N=CN=C32)O[C@@H]1COS(=O)(NC([C@H](CCSC)N)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lee J, et al. N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett. 2003;13(6):1087-1092. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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